CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 309,031	$ 276,472
Short-term investments	2,037,750	1,710,397
Contracts receivable	13,914	25,538
Inventories	22,200	22,033
Other current assets	159,724	168,254
Total current assets	2,542,619	2,202,694
Property, plant and equipment, net	85,158	74,294
Right-of-use assets	179,148	181,544
Deposits and other assets	78,296	75,344
Total assets	2,885,221	2,533,876
Current liabilities:
Accounts payable	10,499	17,921
Accrued compensation	18,160	49,178
Accrued liabilities	112,702	140,101
Income taxes payable	17,286	6,249
Current portion of deferred contract revenue	92,335	90,577
Other current liabilities	8,239	7,535
Total current liabilities	259,221	311,561
Long-term deferred contract revenue	272,973	287,768
Liability related to sale of future royalties, net	505,081	0
Long-term lease liabilities	177,000	178,941
Long-term mortgage debt	8,811	8,847
Long-term obligations	7,487	7,126
Total liabilities	2,398,651	1,960,989
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 143,022,539 and 142,057,736 shares issued and outstanding at March 31, 2023 (unaudited) and December 31, 2022, respectively	143	142
Additional paid-in capital	2,089,358	2,059,850
Accumulated other comprehensive loss	(48,983)	(57,480)
Accumulated deficit	(1,553,948)	(1,429,625)
Total stockholders' equity	486,570	572,887
Total liabilities and stockholders' equity	2,885,221	2,533,876
0 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	623,025	622,242
0.125 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes, net	$ 545,053	$ 544,504