<SEC-DOCUMENT>0000874015-23-000099-index.html : 20230214
<SEC-HEADER>0000874015-23-000099.hdr.sgml : 20230214
<ACCEPTANCE-DATETIME>20230214165328
ACCESSION NUMBER:		0000874015-23-000099
CONFORMED SUBMISSION TYPE:	5
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20221231
FILED AS OF DATE:		20230214
DATE AS OF CHANGE:		20230214

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Hayden Michael R
		CENTRAL INDEX KEY:			0001352908

	FILING VALUES:
		FORM TYPE:		5
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		23630967

	MAIL ADDRESS:	
		STREET 1:		C/O ASPREVA PHARMACEUTICALS CORPORATION
		STREET 2:		1203-4464 MARKHAM STREET
		CITY:			VICTORIA
		STATE:			A1
		ZIP:			V8Z 7X8

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			IONIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			CA
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ISIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19930328
</SEC-HEADER>
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<TYPE>5
<SEQUENCE>1
<FILENAME>primary_doc.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
Document 1 - file: primary_doc.html

Document 1 - RAW XML: primary_doc.xml

</DOCUMENT>
</SEC-DOCUMENT>