Collaborative Arrangements and Licensing Agreements, Bayer (Details) $ in Millions	Sep. 30, 2022 USD ($)
Bayer Collaboration [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received	$ 190

Cumulative amount of payments received under the collaboration agreement as of the end of the reporting period.

No definition available.

Name:	ions_CumulativePaymentsReceived
Namespace Prefix:	ions_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	instant