Significant Accounting Policies, Stock-Based Compensation Expense (Details) $ / shares in Units, $ in Thousands		3 Months Ended		9 Months Ended
		Sep. 30, 2022 USD ($)	Sep. 30, 2021 USD ($)	Sep. 30, 2022 USD ($) Period $ / shares shares	Sep. 30, 2021 USD ($) $ / shares
Stock-based Compensation Expense [Abstract]
Stock-based compensation expense		$ 23,837	$ 30,537	$ 74,575	$ 98,419
Cost of Sales [Member]
Stock-based Compensation Expense [Abstract]
Stock-based compensation expense		163	111	376	293
Research, Development and Patent Expense [Member]
Stock-based Compensation Expense [Abstract]
Stock-based compensation expense		17,733	23,332	55,315	71,979
Selling, General and Administrative Expense [Member]
Stock-based Compensation Expense [Abstract]
Stock-based compensation expense		5,941	$ 7,094	18,884	$ 26,147
Stock Options [Member]
Unrecognized Compensation Expense [Abstract]
Unrecognized compensation expense related to non-vested stock options		50,900		$ 50,900
Weighted average period for recognition				1 year 2 months 12 days
Stock Options [Member] | Board of Directors [Member]
Weighted-Average Assumptions [Abstract]
Risk-free interest rate				2.90%	1.20%
Dividend yield				0.00%	0.00%
Volatility				56.20%	55.90%
Expected life				7 years 4 months 24 days	7 years 3 months 18 days
Stock Options [Member] | Employees [Member]
Weighted-Average Assumptions [Abstract]
Risk-free interest rate				1.90%	0.50%
Dividend yield				0.00%	0.00%
Volatility				54.90%	54.30%
Expected life	[1]			6 years 3 months 18 days	4 years 10 months 24 days
Stock Options Granted Prior to January 1, 2022 [Member]
Weighted-Average Assumptions [Abstract]
Award term				7 years
Stock Options Granted on January 1, 2022 and Thereafter [Member]
Weighted-Average Assumptions [Abstract]
Award term				10 years
ESPP [Member]
Weighted-Average Assumptions [Abstract]
Risk-free interest rate				1.20%	0.10%
Dividend yield				0.00%	0.00%
Volatility				50.10%	42.40%
Expected life				6 months	6 months
RSUs [Member]
Unrecognized Compensation Expense [Abstract]
Unrecognized compensation cost related to non-vested units		53,000		$ 53,000
Weighted average period for recognition				1 year 4 months 24 days
RSUs [Member] | Board of Directors [Member]
RSUs and PRSUs [Abstract]
Weighted-average grant date fair value (in dollars per share) | $ / shares				$ 38.06
RSUs [Member] | Board of Directors [Member] | Minimum [Member]
RSUs and PRSUs [Abstract]
Vesting period				1 year
RSUs [Member] | Board of Directors [Member] | Maximum [Member]
RSUs and PRSUs [Abstract]
Vesting period				4 years
RSUs [Member] | Employees [Member]
RSUs and PRSUs [Abstract]
Vesting period				4 years
Weighted-average grant date fair value (in dollars per share) | $ / shares				$ 34.88
PRSUs [Member]
Unrecognized Compensation Expense [Abstract]
Unrecognized compensation cost related to non-vested units		$ 3,400		$ 3,400
Weighted average period for recognition				1 year 1 month 6 days
PRSUs [Member] | Section 16 Officers [Member]
RSUs and PRSUs [Abstract]
Number of performance periods | Period				3
Vesting period				3 years
Number of units guaranteed to vest (in shares) | shares				0
Weighted-average grant date fair value (in dollars per share) | $ / shares				$ 42.28	$ 77.17
PRSUs [Member] | Section 16 Officers [Member] | Minimum [Member]
RSUs and PRSUs [Abstract]
Percentage of units guaranteed to vest				0.00%
PRSUs [Member] | Section 16 Officers [Member] | Maximum [Member]
RSUs and PRSUs [Abstract]
Percentage of units guaranteed to vest				150.00%
PRSUs [Member] | Section 16 Officers [Member] | One-Year Period [Member]
RSUs and PRSUs [Abstract]
Vesting percentage				33.30%
PRSUs [Member] | Section 16 Officers [Member] | Two-Year Period [Member]
RSUs and PRSUs [Abstract]
Vesting percentage				33.30%
PRSUs [Member] | Section 16 Officers [Member] | Three-Year Period [Member]
RSUs and PRSUs [Abstract]
Vesting percentage				33.30%

[1] In 2021, our Compensation Committee approved an amendment to the 2011 Equity Incentive Plan, or 2011 Plan, and 2020 Plan, that increased the contractual term of stock options granted under these plans from seven years to ten years for stock options granted on January 1, 2022 and thereafter. We determined that we are unable to rely on our historical exercise data as a basis for estimating the expected life of stock options granted to employees following this change because the contractual term changed and we have no other means to reasonably estimate future exercise behavior. We therefore used the simplified method for determining the expected life of stock options granted to employees in the nine months ended September 30, 2022. Under the simplified method, we calculate the expected term as the average of the time-to-vesting and the contractual life of the options. As we gain additional historical information, we will transition to calculating our expected term based on our historical exercise patterns.