Significant Accounting Policies, Accrued Liabilities (Details) - USD ($) $ in Thousands	Sep. 30, 2022	Dec. 31, 2021
Accrued Liabilities [Abstract]
Clinical development expenses	$ 103,635	$ 65,730
In-licensing expenses	7,130	8,044
Commercial expenses	4,188	2,471
Other miscellaneous expenses	13,049	12,315
Total accrued liabilities	$ 128,002	$ 88,560