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Collaborative Arrangements and Licensing Agreements, Roche (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2022
USD ($)
Jun. 30, 2022
USD ($)
Indication
Agreement
Jun. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
Indication
Agreement
Jun. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue   $ 133,791 $ 125,750 $ 275,710 $ 237,357  
R&D Revenue [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue   $ 55,607 39,889 $ 125,242 67,048  
Roche [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of collaboration agreements | Agreement   2   2    
Revenue   $ 19,500 $ 3,600 $ 23,900 $ 7,500  
Deferred revenue   29,700   29,700   $ 31,600
Roche [Member] | Minimum [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Cumulative payments received   $ 245,000   $ 245,000    
Roche [Member] | Revenue [Member] | Strategic Partner [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Concentration percentage   15.00% 3.00% 9.00% 3.00%  
IONIS-FB-L for Complement-Mediated Diseases [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of collaboration agreements | Agreement   1   1    
Number of disease indications | Indication   2   2    
Revenue   $ 13,800        
Milestone payment received and added to transaction price   $ 20,000        
IONIS-FB-L for Complement-Mediated Diseases [Member] | Subsequent Event [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Maximum amount of payments receivable for development milestones $ 145,000          
Maximum amount of payments receivable for regulatory milestones 279,000          
Maximum amount of payments receivable for sales-related milestones 280,000          
Revenue 35,000          
IONIS-FB-L for Complement-Mediated Diseases [Member] | Maximum [Member] | Plan [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Next prospective milestone $ 90,000          
IONIS-FB-L for Complement-Mediated Diseases [Member] | Maximum [Member] | Subsequent Event [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Royalty percentage received on net sales of medicine 20.00%          
IONIS-FB-L for Complement-Mediated Diseases [Member] | GA [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of disease indications | Indication   1   1    
IONIS-FB-L for Complement-Mediated Diseases [Member] | IgAN [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of disease indications | Indication   1   1    
Huntington's Disease [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of collaboration agreements | Agreement   1   1