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Collaborative Arrangements and Licensing Agreements, Biogen (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Jul. 31, 2022
USD ($)
Jun. 30, 2022
USD ($)
Mar. 31, 2022
USD ($)
Target
Jun. 30, 2021
USD ($)
Jun. 30, 2022
USD ($)
Jun. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue   $ 133,791   $ 125,750 $ 275,710 $ 237,357  
SPINRAZA Royalties [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue   59,627   72,168 113,444 132,154  
R&D Revenue [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue   55,607   39,889 125,242 67,048  
Biogen [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Cumulative payments received   3,300,000     3,300,000    
Revenue   76,900   $ 100,000 170,800 $ 178,100  
Deferred revenue   $ 368,300     $ 368,300   $ 407,500
Biogen [Member] | Revenue [Member] | Strategic Partner [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Concentration percentage   58.00%   80.00% 62.00% 75.00%  
Biogen [Member] | SPINRAZA Royalties [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue   $ 59,600   $ 72,200 $ 113,400 $ 132,200  
Biogen [Member] | R&D Revenue [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue   $ 17,300   $ 27,800 $ 57,400 $ 45,900  
2013 Strategic Neurology [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue     $ 18,000        
Number of targets advanced | Target     2        
2013 Strategic Neurology [Member] | Subsequent Event [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Revenue $ 9,000            
2013 Strategic Neurology [Member] | Maximum [Member] | Plan [Member]              
Collaborative Arrangement and Licensing Agreement [Abstract]              
Next prospective payment $ 10,000