Investments, Summary of Investments (Details) $ in Thousands		3 Months Ended	12 Months Ended
		Mar. 31, 2022 USD ($) Company	Dec. 31, 2021 USD ($)
Ownership Interests in Private and Public Companies [Abstract]
Number of private companies in which there is an equity ownership interest of less than 20% | Company		7
Number of public companies in which there is an equity ownership interest of less than 20% | Company		3
Summary of Investments [Abstract]
Amortized cost		$ 1,602,517	$ 1,278,684
Gross unrealized gains		20,880	25,115
Gross unrealized losses		(23,308)	(5,148)
Estimated fair value		$ 1,600,089	1,298,651
Number of publicly traded companies in which there is an investment included in other current assets | Company		2
Bicycle [Member]
Summary of Investments [Abstract]
Gross unrealized losses		$ (3,200)
ProQR [Member]
Summary of Investments [Abstract]
Gross unrealized losses		(3,400)
Available-for-sale Securities [Member]
Summary of Investments [Abstract]
Amortized cost		1,567,505	1,251,172
Gross unrealized gains		227	1,263
Gross unrealized losses		(19,034)	(4,311)
Estimated fair value		1,548,698	1,248,124
Available-for-sale Securities [Member] | Securities with Maturity of One Year or Less [Member]
Summary of Investments [Abstract]
Amortized cost		949,813	612,557
Gross unrealized gains		133	792
Gross unrealized losses		(3,423)	(345)
Estimated fair value		946,523	613,004
Available-for-sale Securities [Member] | Securities with Maturity of More than One Year [Member]
Summary of Investments [Abstract]
Amortized cost		617,692	638,615
Gross unrealized gains		94	471
Gross unrealized losses		(15,611)	(3,966)
Estimated fair value		602,175	635,120
Corporate Debt Securities [Member] | Securities with Maturity of One Year or Less [Member]
Summary of Investments [Abstract]
Amortized cost	[1]	420,081	383,870
Gross unrealized gains		131	728
Gross unrealized losses		(1,766)	(226)
Estimated fair value		418,446	384,372
Corporate Debt Securities [Member] | Securities with Maturity of More than One Year [Member]
Summary of Investments [Abstract]
Amortized cost		345,813	382,000
Gross unrealized gains		24	331
Gross unrealized losses		(10,275)	(2,644)
Estimated fair value		335,562	379,687
Debt Securities Issued by U.S. Government Agencies [Member] | Securities with Maturity of One Year or Less [Member]
Summary of Investments [Abstract]
Amortized cost		34,407	48,493
Gross unrealized gains		0	19
Gross unrealized losses		(49)	(18)
Estimated fair value		34,358	48,494
Debt Securities Issued by U.S. Government Agencies [Member] | Securities with Maturity of More than One Year [Member]
Summary of Investments [Abstract]
Amortized cost		72,844	72,935
Gross unrealized gains		0	0
Gross unrealized losses		(1,974)	(561)
Estimated fair value		70,870	72,374
Debt Securities Issued by the U.S. Treasury [Member] | Securities with Maturity of One Year or Less [Member]
Summary of Investments [Abstract]
Amortized cost	[1]	330,358	45,424
Gross unrealized gains		1	0
Gross unrealized losses		(1,133)	(64)
Estimated fair value		329,226	45,360
Debt Securities Issued by the U.S. Treasury [Member] | Securities with Maturity of More than One Year [Member]
Summary of Investments [Abstract]
Amortized cost		164,040	137,635
Gross unrealized gains		70	139
Gross unrealized losses		(2,544)	(500)
Estimated fair value		161,566	137,274
Debt Securities Issued by States of the U.S. and Political Subdivisions of the States [Member] | Securities with Maturity of One Year or Less [Member]
Summary of Investments [Abstract]
Amortized cost		158,548	134,770
Gross unrealized gains		1	45
Gross unrealized losses		(376)	(37)
Estimated fair value		158,173	134,778
Debt Securities Issued by States of the U.S. and Political Subdivisions of the States [Member] | Securities with Maturity of More than One Year [Member]
Summary of Investments [Abstract]
Amortized cost		34,995	39,909
Gross unrealized gains		0	1
Gross unrealized losses		(818)	(224)
Estimated fair value		34,177	39,686
Other Municipal Debt Securities [Member] | Securities with Maturity of One Year or Less [Member]
Summary of Investments [Abstract]
Amortized cost		6,419
Gross unrealized gains		0
Gross unrealized losses		(99)
Estimated fair value		6,320
Other Municipal Debt Securities [Member] | Securities with Maturity of More than One Year [Member]
Summary of Investments [Abstract]
Amortized cost			6,136
Gross unrealized gains			0
Gross unrealized losses			(37)
Estimated fair value			6,099
Equity Securities [Member]
Summary of Investments [Abstract]
Amortized cost		35,012	27,512
Gross unrealized gains		20,653	23,852
Gross unrealized losses		(4,274)	(837)
Estimated fair value		51,391	50,527
Equity Securities in Publicly Traded Company [Member]
Summary of Investments [Abstract]
Amortized cost	[2]	11,897	11,897
Gross unrealized gains		3,946	7,145
Gross unrealized losses		(4,274)	(837)
Estimated fair value		11,569	18,205
Equity Securities in Private Companies [Member]
Summary of Investments [Abstract]
Amortized cost	[3]	23,115	15,615
Gross unrealized gains		16,707	16,707
Gross unrealized losses		0	0
Estimated fair value		$ 39,822	$ 32,322

[1] Includes investments classified as cash equivalents on our condensed consolidated balance sheet.

[2] Our equity securities included in other current assets consisted of our investments in two publicly traded companies, ProQR and Bicycle, which we classify as Level 1 and Level 3 investments, respectively. We recognize publicly traded equity securities at fair value. In the three months ended March 31, 2022, we recognized a $3.4 million and a $3.2 million unrealized loss on our condensed consolidated statement of operations related to our investments in ProQR and Bicycle, respectively. In the three months ended March 31, 2021, our equity securities included in other current assets only consisted of ProQR.

[3] Our equity securities included in deposits and other assets consisted of our investments in privately held companies. We recognize our private company equity securities at cost minus impairments, plus or minus changes resulting from observable price changes in orderly transactions for the identical or similar investment of the same issuer.