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Cumulative amount of payments received under the collaboration agreement as of the end of the reporting period.

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The maximum amount of payments receivable for development milestones under the collaboration agreement.

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The maximum amount of payments receivable for regulatory milestones under the collaboration agreement.

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The maximum amount of payments receivable for sales milestones under the collaboration agreement.

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The minimum amount of payments receivable for license fees and milestone payments under the collaboration agreement.

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The next potential payment to be earned under the collaboration agreement.

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The number of medicines currently being developed under the collaboration agreement(s).

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The amount of upfront payments received during the period under the collaboration agreement.

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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Collaborative Arrangements and Licensing Agreements, GSK (Details) $ in Thousands	1 Months Ended	3 Months Ended	12 Months Ended
	Mar. 31, 2010 USD ($)	Sep. 30, 2019 USD ($)	Dec. 31, 2021 USD ($) Medicine	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue			$ 810,456	$ 729,264	$ 1,122,599
R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue			$ 468,061	364,565	$ 770,149
GSK [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Upfront payment received	$ 35,000
Number of medicines currently being developed \| Medicine			2
Minimum amount of payments receivable for license fees and milestones			$ 260,000
Maximum amount of payments receivable for development milestones			47,500
Maximum amount of payments receivable for regulatory milestones			120,000
Maximum amount of payments receivable for sales milestones			70,000
Next prospective payment			15,000
Revenue		$ 25,000
Deferred revenue			$ 0	$ 0
GSK [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage			0.00%	0.00%	2.00%
GSK [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received			$ 190,000
GSK [Member] \| R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue			$ 0	$ 200	$ 25,400