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Cumulative amount of payments received under the collaboration agreement as of the end of the reporting period.

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The maximum amount of payments receivable for development, commercialization and sales milestones under the collaboration agreement.

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The maximum amount of payments receivable for development milestones under the collaboration agreement.

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Maximum amount of payments receivable for license fees, milestone payments and other payments under the collaboration agreement.

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The maximum amount of payments receivable for regulatory milestones under the collaboration agreement.

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The maximum amount of payments receivable for sales milestones under the collaboration agreement.

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The maximum amount of payments receivable for milestone payments for each medicine that achieves marketing approval under the collaboration agreement.

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The maximum amount of payments receivable per program for development milestone payments under the collaboration agreement.

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The maximum amount of payments receivable per program for regulatory milestone payments under the collaboration agreement.

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Milestone payments achieved under the collaboration agreement during the period and included in the transaction price for the performance obligation.

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The next potential payment to be earned under the collaboration agreement.

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The number of medicines currently being developed under the collaboration agreement(s).

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The percentage cash premium paid per share of the Company's common stock under the collaboration agreement.

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The number of separate performance obligations under the collaboration agreement.

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Royalty percentage received on the net sales of a medicine by a collaboration partner under the collaboration agreement.

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Term of the collaboration agreement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Term of long-term open label extension study, in which patients participating in double blind placebo controlled trials of new medications are invited, on completion of the initial trial, to take the study drug for some further period, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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The total amount of the upfront payment received, including the purchase of shares of the Company's stock, under the collaboration agreement.

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For an entity that discloses a concentration risk in relation to quantitative amount, which serves as the "benchmark" (or denominator) in the equation, this concept represents the concentration percentage derived from the division.

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Amount of obligation to transfer good or service to customer for which consideration has been received or is receivable.

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The cash inflow from the additional capital contribution to the entity.

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Collaborative Arrangements and Licensing Agreements, Biogen (Details) $ in Thousands	1 Months Ended			3 Months Ended						12 Months Ended
	Dec. 31, 2021 USD ($) Medicine Program	Sep. 30, 2013 USD ($) PerformanceObligation	Dec. 31, 2012 USD ($) Program	Dec. 31, 2021 USD ($) Medicine Program	Jun. 30, 2021 USD ($)	Dec. 31, 2019 USD ($)	Sep. 30, 2019 USD ($)	Jun. 30, 2018 USD ($)	Dec. 31, 2017 USD ($) PerformanceObligation	Dec. 31, 2021 USD ($) Medicine Program	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Apr. 30, 2018 USD ($) PerformanceObligation
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue										$ 810,456	$ 729,264	$ 1,122,599
SPINRAZA Royalties [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue										267,776	286,583	292,992
R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue										$ 468,061	364,565	770,149
Biogen [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of medicines currently being developed \| Medicine	9			9						9
Revenue										$ 428,800	408,600	$ 473,600
Deferred revenue	$ 407,500			$ 407,500						$ 407,500	$ 465,800
Biogen [Member] \| Revenue [Member] \| Strategic Partner [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Concentration percentage										53.00%	56.00%	42.00%
Biogen [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received	3,100,000			3,100,000						$ 3,100,000
Biogen [Member] \| SPINRAZA Royalties [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue										267,800	$ 286,600	$ 293,000
Biogen [Member] \| R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue										161,000	122,000	$ 180,600
SPINRAZA [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative revenue earned	1,600,000			1,600,000						$ 1,600,000
Royalty percentage received on net sales of medicine										11.00%
SPINRAZA [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine										15.00%
SPINRAZA [Member] \| SPINRAZA Royalties [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative revenue earned	1,200,000			1,200,000						$ 1,200,000
SPINRAZA [Member] \| R&D Revenue [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative revenue earned	435,000			435,000						$ 435,000
New Antisense Medicines for the Treatment of SMA [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine										20.00%
Upfront payment received									$ 25,000
Maximum amount of payments receivable for license fees, milestone payments and other payments	1,200,000			1,200,000						$ 1,200,000
Next prospective payment	45,000			45,000						45,000
Number of separate performance obligations \| PerformanceObligation									1
Transaction price									$ 25,000
Revenue						$ 8,300
New Antisense Medicines for the Treatment of SMA [Member] \| ION306 [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable for development, commercialization and sales milestones	555,000			555,000						555,000
Maximum amount of payments receivable for development milestones	45,000			45,000						45,000
Maximum amount of payments receivable for regulatory milestones	110,000			110,000						110,000
Maximum amount of payments receivable for sales milestones	400,000			400,000						$ 400,000
Revenue	60,000			60,000
2018 Strategic Neurology [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Royalty percentage received on net sales of medicine										20.00%
Upfront payment received								$ 375,000
Next prospective payment	7,500			7,500						$ 7,500
Number of separate performance obligations \| PerformanceObligation													1
Transaction price													$ 552,000
Term of collaboration agreement										10 years
Upfront payment received, including purchase of stock								1,000,000
Proceeds from issuance of common stock								$ 625,000
Percentage cash premium paid on shares purchased								25.00%
Maximum amount of payments receivable per medicine for milestone payments	$ 270,000			$ 270,000						$ 270,000
Number of programs being advanced \| Program	9			9						9
Premium paid on shares purchased								$ 177,000
Cumulative payments included in transaction price for performance obligation	$ 616,000			$ 616,000						$ 616,000
Milestone payments achieved and included in transaction price for performance obligation										23,000	11,000
Revenue				15,000
2018 Strategic Neurology [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received	1,100,000			1,100,000						1,100,000
2013 Strategic Neurology [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Upfront payment received		$ 100,000
Next prospective payment	$ 70,000			$ 70,000						$ 70,000
Number of separate performance obligations \| PerformanceObligation		1
Transaction price		$ 100,000
Number of medicines currently being advanced \| Medicine	6			6						6
Revenue							$ (16,500)
2013 Strategic Neurology [Member] \| Minimum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received	$ 280,000			$ 280,000						$ 280,000
2013 Strategic Neurology [Member] \| R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments included in transaction price for performance obligation											145,000
2013 Strategic Neurology [Member] \| Medicines for Parkinson's Disease [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of medicines currently being advanced \| Medicine	1			1						1
2013 Strategic Neurology [Member] \| Medicines for ALS [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of medicines currently being advanced \| Medicine	3			3						3
2013 Strategic Neurology [Member] \| Medicines for Multiple System Atrophy [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of medicines currently being advanced \| Medicine	1			1						1
2013 Strategic Neurology [Member] \| Medicines for Undisclosed Targets [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of medicines currently being advanced \| Medicine	1			1						1
2013 Strategic Neurology [Member] \| Antisense Molecule [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable per program for license fee and milestone payments	$ 260,000			$ 260,000						$ 260,000
Maximum amount of payments receivable per program for development milestones	60,000			60,000						60,000
Maximum amount of payments receivable per program for regulatory milestones	130,000			130,000						130,000
2013 Strategic Neurology [Member] \| ION541 [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue					$ 10,000
2012 Neurology [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received	155,000			155,000						155,000
Upfront payment received			$ 30,000
Next prospective payment	25,000			25,000						25,000
Maximum amount of payments receivable per program for license fee and milestone payments	210,000			210,000						210,000
Maximum amount of payments receivable per program for development milestones	10,000			10,000						10,000
Maximum amount of payments receivable per program for regulatory milestones	130,000			130,000						130,000
Number of programs under which medicines are to be developed and commercialized \| Program			3
Revenue							$ 6,300
2012 Neurology [Member] \| R&D Revenue [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments included in transaction price for performance obligation	40,000			40,000						40,000
2012 Neurology [Member] \| IONIS-MAPT [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments included in transaction price for performance obligation	$ 57,000			57,000						$ 57,000
Milestone payments achieved and included in transaction price for performance obligation											$ 19,500
Term of extension study										1 year
Revenue						$ 45,000
2012 Neurology [Member] \| ION582 [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue				$ 10,000