Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2021
Deferred Tax Assets [Abstract]
Net operating loss carryovers	$ 83,681	$ 85,600
Tax credits	245,746	269,538
Deferred revenue	124,452	104,330
Stock-based compensation	80,055	86,611
Intangible and capital assets	98,443	92,542
Convertible debt	22,395	45,681
Interest expense limitation	0	6,996
Other	13,402	15,048
Total deferred tax assets	668,174	706,346
Deferred Tax Liabilities [Abstract]
Fixed assets	(3,611)	(3,303)
Other	(5,808)	(5,270)
Net deferred tax asset	658,755	697,773
Valuation allowance	(658,755)	(697,773)
Total net deferred tax assets and liabilities	0	0
Increase in valuation allowance	$ 341,000	$ 39,000