Stockholders' Equity, Stock-based Compensation Expense (Details) $ in Thousands	3 Months Ended	12 Months Ended
	Sep. 30, 2019 USD ($) Officer	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Oct. 31, 2020 USD ($)
Stock-Based Compensation [Abstract]
Stock-based compensation expense		$ 120,678	$ 230,117	$ 146,574
Cost of Sales [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense		456	1,991	438
Research, Development and Patent [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense		87,522	115,584	95,348
Selling, General and Administrative [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense		$ 32,700	$ 112,542	$ 50,788
Akcea [Member]
Stock-Based Compensation [Abstract]
Stock-based compensation expense	$ (19,100)
Unrecognized compensation cost related to non-vested units					$ 59,300
Number of executive officers terminating employment | Officer	3