Organization and Significant Accounting Policies, Cash, Cash Equivalents and Investments (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2021 USD ($) Company	Dec. 31, 2020 USD ($) Investment	Dec. 31, 2019 USD ($)
Cash, Cash Equivalents and Investments [Abstract]
Number of publicly held companies in which there is an equity ownership interest of less than 20% | Company	3
Number of privately held companies in which there is an equity ownership interest of less than 20% | Company	7
Number of investments in privately held companies that were revalued | Investment		3
Gain on investment	$ 10,103	$ 16,540	$ 192
Dynacure [Member]
Cash, Cash Equivalents and Investments [Abstract]
Gain on investment		6,300
Suzhou-Ribo [Member]
Cash, Cash Equivalents and Investments [Abstract]
Gain on investment		3,000
Aro Biotherapeutics [Member]
Cash, Cash Equivalents and Investments [Abstract]
Gain on investment		$ 5,500