Organization and Significant Accounting Policies, Accrued Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Accrued Liabilities [Abstract]
Clincial expenses	$ 65,730	$ 39,477
In-licensing expenses	8,044	8,264
Commercial expenses	2,471	11,559
Other miscellaneous expenses	12,315	30,861
Total accrued liabilities	$ 88,560	$ 90,161