Organization and Significant Accounting Policies, Research, Development and Patent Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Research, Development and Patent Expenses [Abstract]
Research and development expenses	$ 638,200	$ 531,000	$ 461,500
Estimated Amortization Expense [Abstract]
Non-cash charges related to write-down	2,707	1,948	2,226
Patents [Member]
Research, Development and Patent Expenses [Abstract]
Research and development expenses	$ 5,300	4,100	4,200
Estimated useful life	10 years 2 months 12 days
Cost	$ 38,400	37,000
Accumulated amortization	9,400	9,100
Estimated Amortization Expense [Abstract]
2022	2,200
2023	2,100
2024	1,900
2025	1,800
2026	1,800
Non-cash charges related to write-down	$ 2,700	$ 1,900	$ 2,200