Organization and Significant Accounting Policies, Basis of Presentation (Details) - Akcea [Member]	Dec. 31, 2021	Oct. 31, 2020	Sep. 30, 2020	Jun. 30, 2017
Basis of Presentation [Abstract]
Percentage ownership	100.00%	100.00%	76.00%
Maximum [Member]
Basis of Presentation [Abstract]
Percentage ownership		77.00%		100.00%