Number of separate performance periods under share-based payment arrangement.

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- Definition

Number of units guaranteed to vest under share-based payment arrangement.

+ References

No definition available.

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- Definition

Percentage of units guaranteed to vest under share-based payment arrangement.

+ References

No definition available.

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
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- References

No definition available.

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- Definition

Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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- Definition

Amount of cost to be recognized for nonvested award under share-based payment arrangement. Excludes share and unit options.

+ References

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- Definition

Amount of cost to be recognized for option under share-based payment arrangement.

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- Definition

Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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- Definition

The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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- Definition

The risk-free interest rate assumption that is used in valuing an option on its own shares.

+ References

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- Definition

Rate of weighted-average expected volatility for award under share-based payment arrangement.

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- Definition

The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

+ References

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- Definition

Percentage of vesting of award under share-based payment arrangement.

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- Definition

Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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Significant Accounting Policies, Stock-Based Compensation Expense (Details) $ / shares in Units, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021 USD ($)	Sep. 30, 2020 USD ($)	Sep. 30, 2021 USD ($) Period $ / shares shares	Sep. 30, 2020 USD ($)
Stock-based Compensation Expense [Abstract]
Non-cash stock-based compensation expense	$ 30,537	$ 45,845	$ 98,419	$ 135,077
Cost of Sales [Member]
Stock-based Compensation Expense [Abstract]
Non-cash stock-based compensation expense	111	315	293	902
Research, Development and Patent Expense [Member]
Stock-based Compensation Expense [Abstract]
Non-cash stock-based compensation expense	23,332	25,359	71,979	76,931
Selling, General and Administrative Expense [Member]
Stock-based Compensation Expense [Abstract]
Non-cash stock-based compensation expense	7,094	$ 20,171	26,147	$ 57,244
Stock Options [Member]
Unrecognized Compensation Expense [Abstract]
Unrecognized compensation expense related to non-vested stock options	65,300		$ 65,300
Weighted average period for recognition			1 year 2 months 12 days
Stock Options [Member] \| Board of Directors [Member]
Weighted-Average Assumptions [Abstract]
Risk-free interest rate			1.20%	0.50%
Dividend yield			0.00%	0.00%
Volatility			55.90%	57.60%
Expected life			7 years 3 months 18 days	6 years 8 months 12 days
Stock Options [Member] \| Employees [Member]
Weighted-Average Assumptions [Abstract]
Risk-free interest rate			0.50%	1.50%
Dividend yield			0.00%	0.00%
Volatility			54.30%	58.80%
Expected life			4 years 10 months 24 days	4 years 8 months 12 days
ESPP [Member]
Weighted-Average Assumptions [Abstract]
Risk-free interest rate			0.10%	0.80%
Dividend yield			0.00%	0.00%
Volatility			42.40%	47.90%
Expected life			6 months	6 months
RSUs [Member]
Unrecognized Compensation Expense [Abstract]
Unrecognized compensation cost related to non-vested units	72,200		$ 72,200
Weighted average period for recognition			1 year 4 months 24 days
RSUs [Member] \| Board of Directors [Member]
RSUs and PRSUs [Abstract]
Weighted-average grant date fair value (in dollars per share) \| $ / shares			$ 39.42
RSUs [Member] \| Board of Directors [Member] \| Maximum [Member]
RSUs and PRSUs [Abstract]
Vesting period			4 years
RSUs [Member] \| Board of Directors [Member] \| Minimum [Member]
RSUs and PRSUs [Abstract]
Vesting period			1 year
RSUs [Member] \| Employees [Member]
RSUs and PRSUs [Abstract]
Vesting period			4 years
Weighted-average grant date fair value (in dollars per share) \| $ / shares			$ 59.15
PRSUs [Member]
Unrecognized Compensation Expense [Abstract]
Unrecognized compensation cost related to non-vested units	$ 2,500		$ 2,500
Weighted average period for recognition			1 year 2 months 12 days
PRSUs [Member] \| Chief Executive Officer, Dr. Brett Monia [Member]
RSUs and PRSUs [Abstract]
Number of performance periods \| Period			3
Vesting period			3 years
Number of units guaranteed to vest \| shares			0
Weighted-average grant date fair value (in dollars per share) \| $ / shares			$ 77.17
PRSUs [Member] \| Chief Executive Officer, Dr. Brett Monia [Member] \| Maximum [Member]
RSUs and PRSUs [Abstract]
Percentage of units guaranteed to vest			150.00%
PRSUs [Member] \| Chief Executive Officer, Dr. Brett Monia [Member] \| Minimum [Member]
RSUs and PRSUs [Abstract]
Percentage of units guaranteed to vest			0.00%
PRSUs [Member] \| Chief Executive Officer, Dr. Brett Monia [Member] \| One-Year Period [Member]
RSUs and PRSUs [Abstract]
Vesting percentage			33.30%
PRSUs [Member] \| Chief Executive Officer, Dr. Brett Monia [Member] \| Two-Year Period [Member]
RSUs and PRSUs [Abstract]
Vesting percentage			33.30%
PRSUs [Member] \| Chief Executive Officer, Dr. Brett Monia [Member] \| Three-Year Period [Member]
RSUs and PRSUs [Abstract]
Vesting percentage			33.30%