Amount, excluding tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value added and excise.

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Collaborative Arrangements and Licensing Agreements, Novartis (Details) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
	Aug. 04, 2021	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue		$ 125,750	$ 145,537	$ 237,357	$ 278,905
Novartis [Member] \| Maximum [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative payments received		$ 400,000		$ 400,000
Novartis [Member] \| Maximum [Member] \| Plan [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Next prospective milestone	$ 75,000
Novartis [Member] \| Pelacarsen [Member] \| Subsequent Event [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue	$ 25,000
Percentage enrollment in Phase 3 study	50.00%