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Collaborative Arrangements and Licensing Agreements, Roche (Details)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2019
USD ($)
Agreement
Mar. 31, 2019
USD ($)
Sep. 30, 2018
USD ($)
Sep. 30, 2019
USD ($)
Agreement
Sep. 30, 2018
USD ($)
Dec. 31, 2018
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue $ 167,892   $ 145,395 $ 628,918 $ 407,559  
R&D Revenue [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue $ 72,193   $ 62,639 $ 376,833 $ 225,584  
Roche [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of collaboration agreements | Agreement 2     2    
Deferred revenue $ 56,700     $ 56,700   $ 72,600
Roche [Member] | Revenue [Member] | Strategic Partner [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Concentration percentage 3.00%   1.00% 8.00% 1.00%  
Roche [Member] | R&D Revenue [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue $ 4,700   $ 1,800 $ 52,300 $ 5,400  
Huntington's Disease [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of collaboration agreements | Agreement 1     1    
Cumulative payments received $ 220,000     $ 220,000    
Next prospective milestone $ 15,000     $ 15,000    
Revenue   $ 35,000        
IONIS-FB-L for Complement-Mediated Diseases [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of collaboration agreements | Agreement 1     1