CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash and cash equivalents	$ 375,811	$ 278,820
Short-term investments	1,877,943	1,805,252
Contracts receivable	10,452	12,759
Inventories	11,057	8,582
Other current assets	98,686	102,473
Total current assets	2,373,949	2,207,886
Property, plant and equipment, net	133,519	132,160
Patents, net	25,220	24,032
Long-term deferred tax assets	277,247	290,796
Deposits and other assets	25,954	12,910
Total assets	2,835,889	2,667,784
Current liabilities:
Accounts payable	13,332	28,660
Accrued compensation	16,264	29,268
Accrued liabilities	45,130	47,503
Income taxes payable	18,401	858
Current portion of long-term obligations	14,500	13,749
Current portion of deferred contract revenue	144,846	160,256
Total current liabilities	252,473	280,294
Long-term deferred contract revenue	542,416	567,359
1 percent convertible senior notes	577,415	568,215
Long-term obligations, less current portion	16,305	4,914
Long-term mortgage debt	59,860	59,842
Total liabilities	1,448,469	1,480,624
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 139,623,937 and 137,928,828 shares issued and outstanding at March 31, 2019 (unaudited) and December 31, 2018, respectively	140	138
Additional paid-in capital	2,117,969	2,047,250
Accumulated other comprehensive loss	(27,608)	(32,016)
Accumulated deficit	(882,850)	(967,293)
Total Ionis stockholders' equity	1,207,651	1,048,079
Noncontrolling interest in Akcea Therapeutics, Inc.	179,769	139,081
Total stockholders' equity	1,387,420	1,187,160
Total liabilities and stockholders' equity	$ 2,835,889	$ 2,667,784