CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 278,820	$ 129,630
Short-term investments	1,805,252	893,085
Contracts receivable	12,759	62,955
Inventories	8,582	9,982
Other current assets	102,473	73,082
Total current assets	2,207,886	1,168,734
Property, plant and equipment, net	132,160	121,907
Patents, net	24,032	22,004
Long-term deferred tax assets	290,796	0
Deposits and other assets	12,910	10,129
Total assets	2,667,784	1,322,774
Current liabilities:
Accounts payable	28,660	24,886
Accrued compensation	29,268	25,151
Accrued liabilities	48,361	66,618
Current portion of long-term obligations	13,749	1,621
Current portion of deferred contract revenue	160,256	125,336
Total current liabilities	280,294	243,612
Long-term deferred contract revenue	567,359	108,026
1 percent convertible senior notes	568,215	533,111
Long-term obligations, less current portion	4,914	12,974
Long-term mortgage debt	59,842	59,771
Total liabilities	1,480,624	957,494
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 137,928,828 and 124,976,373 shares issued and outstanding at December 31, 2018 and December 31, 2017, respectively	138	125
Additional paid-in capital	2,047,250	1,553,681
Accumulated other comprehensive loss	(32,016)	(31,759)
Accumulated deficit	(967,293)	(1,241,034)
Total Ionis stockholders' equity	1,048,079	281,013
Noncontrolling interest in Akcea Therapeutics, Inc.	139,081	84,267
Total stockholders' equity	1,187,160	365,280
Total liabilities and stockholders' equity	$ 2,667,784	$ 1,322,774