CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 805,490	$ 129,630
Short-term investments	1,174,960	893,085
Contracts receivable	16,761	62,955
Inventories	9,067	9,982
Other current assets	76,994	73,082
Total current assets	2,083,272	1,168,734
Property, plant and equipment, net	127,940	121,907
Patents, net	23,452	22,004
Deposits and other assets	12,651	10,129
Total assets	2,247,315	1,322,774
Current liabilities:
Accounts payable	13,291	24,886
Accrued compensation	15,089	25,151
Accrued liabilities	58,486	66,618
Current portion of long-term obligations	1,164	1,621
Current portion of deferred contract revenue	160,589	125,336
Total current liabilities	248,619	243,612
Long-term deferred contract revenue	556,586	108,026
1 percent convertible senior notes	550,328	533,111
Long-term obligations, less current portion	14,539	12,974
Long-term mortgage debt	59,807	59,771
Total liabilities	1,429,879	957,494
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 137,156,361 and 124,976,373 shares issued and outstanding at June 30, 2018 and December 31, 2017, respectively	137	125
Additional paid-in capital	2,011,561	1,553,681
Accumulated other comprehensive loss	(32,634)	(31,759)
Accumulated deficit	(1,282,809)	(1,241,034)
Total Ionis stockholders' equity	696,255	281,013
Noncontrolling interest in Akcea Therapeutics, Inc.	121,181	84,267
Total stockholders' equity	817,436	365,280
Total liabilities and stockholders' equity	$ 2,247,315	$ 1,322,774