CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 227,505	$ 129,630
Short-term investments	807,796	893,085
Contracts receivable	36,858	62,955
Inventories	9,060	9,982
Other current assets	62,064	73,082
Total current assets	1,143,283	1,168,734
Property, plant and equipment, net	123,188	121,907
Patents, net	22,914	22,004
Deposits and other assets	10,175	10,129
Total assets	1,299,560	1,322,774
Current liabilities:
Accounts payable	13,833	24,886
Accrued compensation	12,166	25,151
Accrued liabilities	66,470	66,618
Current portion of long-term obligations	47	1,621
Current portion of deferred contract revenue	120,127	125,336
Total current liabilities	212,643	243,612
Long-term deferred contract revenue	85,446	108,026
1 percent convertible senior notes	541,635	533,111
Long-term obligations, less current portion	12,946	12,974
Long-term mortgage debt	59,789	59,771
Total liabilities	912,459	957,494
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 125,448,746 and 124,976,373 shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively	125	125
Additional paid-in capital	1,576,954	1,553,681
Accumulated other comprehensive loss	(33,234)	(31,759)
Accumulated deficit	(1,242,454)	(1,241,034)
Total Ionis stockholders' equity	301,391	281,013
Noncontrolling interest in Akcea Therapeutics, Inc.	85,710	84,267
Total stockholders' equity	387,101	365,280
Total liabilities and stockholders' equity	$ 1,299,560	$ 1,322,774