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Organization and Significant Accounting Policies, Accumulated Other Comprehensive Income (Loss) (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Balance $ 99,565 $ 200,790 $ 257,780
Net other comprehensive loss for the period (1,401) (16,793) (53,312)
Balance 418,719 99,565 200,790
Income tax expense included in other comprehensive income 0 0 0
Accumulated Other Comprehensive (Loss) Income [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Balance (30,358) (13,565) 39,747
Balance (31,759) (30,358) (13,565)
Unrealized Losses on Securities [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Other comprehensive loss before reclassifications, net of tax [1] (960) (17,219) (33,101)
Amounts reclassified from accumulated other comprehensive (loss) income [2] (374) 447 (20,211)
Currency Translation Adjustment [Member]      
Accumulated Other Comprehensive Income (Loss) [Roll Forward]      
Other comprehensive loss before reclassifications, net of tax $ (67) $ (21) $ 0
[1] There was no tax expense for other comprehensive loss for the years ended December 31, 2017, 2016 or 2015.
[2] Amounts for 2015 are included in the separate line called "Gain on investment in Regulus Therapeutics Inc." on our Consolidated Statement of Operations.