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Organization and Significant Accounting Policies, Revenue Recognition (Details)
$ in Thousands, shares in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Feb. 28, 2017
USD ($)
AccountingUnit
May 31, 2015
USD ($)
Dec. 31, 2017
USD ($)
Agreement
Mar. 31, 2017
USD ($)
AccountingUnit
Drug
shares
Jun. 30, 2015
USD ($)
Dec. 31, 2017
USD ($)
Drug
Category
Stage
Partner
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Jan. 31, 2017
USD ($)
Revenue Recognition [Abstract]                  
SPINRAZA royalties           $ 112,540 $ 883 $ 0  
Number of categories of milestone events | Category           3      
Number of stages of life-cycle of drugs | Stage           3      
Number of partners that exercised option to license drugs | Partner           3      
Number of drugs licensed under option in collaboration agreements | Drug           3      
Minimum [Member]                  
Revenue Recognition [Abstract]                  
Period to complete IND-enabling animal studies           12 months      
Period to complete Phase 1 clinical trial           1 year      
Period to complete Phase 2 clinical trial           1 year      
Period to complete Phase 3 clinical trial           2 years      
Period to prepare and submit regulatory filings           6 months      
Period to obtain marketing authorization from applicable regulatory agency           1 year      
Pre-specified product sales threshold included in commercialization milestones           $ 1,000,000      
Maximum [Member]                  
Revenue Recognition [Abstract]                  
Period to complete IND-enabling animal studies           18 months      
Period to complete Phase 1 clinical trial           2 years      
Period to complete Phase 2 clinical trial           3 years      
Period to complete Phase 3 clinical trial           4 years      
Period to prepare and submit regulatory filings           12 months      
Period to obtain marketing authorization from applicable regulatory agency           2 years      
Novartis [Member]                  
Revenue Recognition [Abstract]                  
Number of agreements | Agreement     2            
Bayer [Member]                  
Revenue Recognition [Abstract]                  
Upfront payment received $ 75,000 $ 100,000     $ 100,000        
Bayer [Member]                  
Revenue Recognition [Abstract]                  
Payment received for advancing programs $ 75,000                
Number of units of accounting | AccountingUnit 3                
Allocable arrangement consideration $ 76,300                
Consideration allocated to exclusive license 64,900                
Consideration allocated to development activities 11,000                
Consideration allocated to delivery of API $ 400                
Assumed percentage change in estimated selling price 10.00%                
Percentage change in earned revenue based on assumed change in estimated selling price 1.00%                
Amount by which earned revenue would change based on assumed change in estimated selling price $ 700                
Novartis [Member]                  
Revenue Recognition [Abstract]                  
Number of units of accounting | AccountingUnit       4          
Number of drugs with exclusive option that could be exercised | Drug       1          
Shares issued (in shares) | shares       1.6          
Proceeds from sale of common stock, including premium paid       $ 100,000          
Additional amount of common stock required to be purchased       50,000         $ 50,000
Akcea [Member] | Novartis [Member]                  
Revenue Recognition [Abstract]                  
Upfront payment received       $ 75,000          
License fee receivable per drug     $ 150,000     $ 150,000