CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Current assets:
Cash and cash equivalents	$ 129,630	$ 84,685
Short-term investments	893,085	580,538
Contracts receivable	62,955	108,043
Inventories	9,982	7,489
Other current assets	72,332	17,177
Total current assets	1,167,984	797,932
Property, plant and equipment, net	121,907	92,845
Patents, net	22,004	20,365
Deposits and other assets	10,129	1,325
Total assets	1,322,024	912,467
Current liabilities:
Accounts payable	24,886	21,120
Accrued compensation	25,151	24,186
Accrued liabilities	66,618	36,013
Current portion of long-term obligations	1,621	1,185
Current portion of deferred contract revenue	106,465	51,280
Total current liabilities	224,741	133,784
Long-term deferred contract revenue	72,708	91,198
1 percent convertible senior notes	533,111	500,511
Long-term obligations, less current portion	12,974	15,050
Long-term financing liability for leased facility	0	72,359
Long-term mortgage debt	59,771	0
Total liabilities	903,305	812,902
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 124,976,373 and 121,636,273 shares issued and outstanding at December 31, 2017 and December 31, 2016, respectively	125	122
Additional paid-in capital	1,549,904	1,311,229
Accumulated other comprehensive income (loss)	(31,759)	(30,358)
Accumulated deficit	(1,187,398)	(1,181,428)
Total Ionis stockholders' equity	330,872	99,565
Noncontrolling interest in Akcea Therapeutics, Inc.	87,847	0
Total stockholders' equity	418,719	99,565
Total liabilities and stockholders' equity	$ 1,322,024	$ 912,467