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Collaborative Arrangements and Licensing Agreements, Novartis (Details)
$ in Thousands, shares in Millions
3 Months Ended 6 Months Ended
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
shares
Jun. 30, 2016
USD ($)
Jun. 30, 2017
USD ($)
AccountingUnit
Drug
Jun. 30, 2016
USD ($)
Jan. 31, 2017
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]            
Proceeds from sale of common stock       $ 71,640 $ 0  
Revenue earned $ 104,152   $ 38,470 $ 214,456 $ 75,345  
Novartis [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Shares issued (in shares) | shares   1.6        
Proceeds from sale of common stock   $ 100,000        
Additional amount of common stock required to be purchased in the future           $ 50,000
Number of units of accounting | AccountingUnit       4    
Total consideration under collaboration 180,000     $ 180,000    
Premium received on shares issued   28,400        
Potential premium received if common stock is purchased in the future at a premium 5,000     5,000    
Consideration allocated to equity 71,600     71,600    
Consideration allocated to development services and delivery of API for AKCEA-APO(a)-L and AKCEA-APOCIII-L 108,400     108,400    
Revenue earned 14,100     23,700    
Deferred revenue $ 84,700     $ 84,700    
Novartis [Member] | Revenue [Member] | Strategic Partner [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Concentration percentage 14.00%     11.00%    
Novartis [Member] | Minimum [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of drugs with exclusive option that could be exercised | Drug       1    
Novartis [Member] | AKCEA-APO(a)-L [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Consideration allocated to development activities $ 64,000     $ 64,000    
Consideration allocated to delivery of API 1,500     1,500    
Novartis [Member] | AKCEA-APOCIII-L [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Consideration allocated to development activities 40,100     40,100    
Consideration allocated to delivery of API 2,800     2,800    
Akcea [Member] | Novartis [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Upfront payment received   75,000        
Portion of upfront payment retained   60,000        
Portion of upfront payment paid as a sublicense fee   $ 15,000        
License fee receivable per drug 150,000     150,000    
Next prospective milestone 25,000     $ 25,000    
Percentage of license fees, milestone payments and royalties paid as sublicense fee       50.00%    
Akcea [Member] | Novartis [Member] | AKCEA-APO(a)-L [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Maximum amount of payments receivable for milestones 600,000     $ 600,000    
Maximum amount of payments receivable for development milestones 25,000     25,000    
Maximum amount of payments receivable for regulatory milestones 290,000     290,000    
Maximum amount of payments receivable for commercialization milestones 285,000     $ 285,000    
Royalty percentage received on sales of drug       20.00%    
Akcea [Member] | Novartis [Member] | AKCEA-APOCIII-L [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Maximum amount of payments receivable for milestones 530,000     $ 530,000    
Maximum amount of payments receivable for development milestones 25,000     25,000    
Maximum amount of payments receivable for regulatory milestones 240,000     240,000    
Maximum amount of payments receivable for commercialization milestones $ 265,000     $ 265,000    
Royalty percentage received on sales of drug       20.00%