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Collaborative Arrangements and Licensing Agreements, Bayer (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Apr. 30, 2017
Feb. 28, 2017
Jun. 30, 2015
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2015
Jun. 30, 2017
Jun. 30, 2016
Collaborative Arrangement and Licensing Agreement [Abstract]                
Revenue recorded       $ 81,229 $ 22,455   $ 182,776 $ 57,670
Revenue earned       104,152 38,470   214,456 75,345
Collaboration Agreements with Bayer [Member]                
Collaborative Arrangement and Licensing Agreement [Abstract]                
Cumulative payments received       175,000     175,000  
Bayer [Member]                
Collaborative Arrangement and Licensing Agreement [Abstract]                
Upfront payment received           $ 100,000    
Revenue recorded     $ 91,200          
Revenue earned       1,200 $ 3,700   66,700 $ 5,000
Deferred revenue       $ 9,700     $ 9,700  
Bayer [Member] | Revenue [Member] | Strategic Partner [Member]                
Collaborative Arrangement and Licensing Agreement [Abstract]                
Concentration percentage       1.00% 10.00%   31.00% 7.00%
Bayer [Member]                
Collaborative Arrangement and Licensing Agreement [Abstract]                
Revenue recorded   $ 64,900            
Payment received for advancing programs $ 75,000              
Maximum amount of payments receivable for license fees and substantive milestones       $ 385,000     $ 385,000  
Maximum amount of payments receivable for development milestones       125,000     125,000  
Maximum amount of payments receivable for commercialization milestones       110,000     110,000  
Next prospective milestone       $ 10,000     $ 10,000  
Bayer [Member] | Minimum [Member]                
Collaborative Arrangement and Licensing Agreement [Abstract]                
Royalty percentage received on gross margins of both drugs combined             20.00%