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Significant Accounting Policies, Revenue Recognition (Details)
$ in Thousands, shares in Millions
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Apr. 30, 2017
USD ($)
Feb. 28, 2017
USD ($)
AccountingUnit
Jun. 30, 2017
USD ($)
Mar. 31, 2017
USD ($)
Agreement
shares
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2017
USD ($)
AccountingUnit
Drug
Category
Stage
Jun. 30, 2016
USD ($)
Dec. 31, 2016
Drug
Partner
Jan. 31, 2017
USD ($)
Revenue Recognition [Abstract]                    
SPINRAZA royalties     $ 22,366   $ 0   $ 27,577 $ 0    
Proceeds from sale of common stock             $ 71,640 $ 0    
Number of categories of milestone events | Category             3      
Number of stages of life-cycle of drugs | Stage             3      
Number of partners that exercised option to license drugs | Partner                 3  
Number of drugs licensed under option in collaboration agreements | Drug                 3  
Minimum [Member]                    
Revenue Recognition [Abstract]                    
Period to complete IND-enabling animal studies             12 months      
Period to complete Phase 1 clinical trial             1 year      
Period to complete Phase 2 clinical trial             1 year      
Period to complete Phase 3 clinical trial             2 years      
Period to prepare and submit regulatory filings             6 months      
Period to obtain marketing authorization from applicable regulatory agency             1 year      
Pre-specified product sales threshold included in commercialization milestones             $ 1,000,000      
Maximum [Member]                    
Revenue Recognition [Abstract]                    
Period to complete IND-enabling animal studies             18 months      
Period to complete Phase 1 clinical trial             2 years      
Period to complete Phase 2 clinical trial             3 years      
Period to complete Phase 3 clinical trial             4 years      
Period to prepare and submit regulatory filings             12 months      
Period to obtain marketing authorization from applicable regulatory agency             2 years      
Novartis [Member]                    
Revenue Recognition [Abstract]                    
Number of agreements | Agreement       2            
Bayer [Member]                    
Revenue Recognition [Abstract]                    
Upfront payment received           $ 100,000        
Bayer [Member]                    
Revenue Recognition [Abstract]                    
Payment received for advancing programs $ 75,000                  
Number of units of accounting | AccountingUnit   3                
Allocable arrangement consideration   $ 76,300                
Consideration allocated to exclusive license   64,900                
Consideration allocated to development activities   11,000                
Consideration allocated to delivery of API   $ 400                
Assumed percentage change in estimated selling price   10.00%                
Percentage change in earned revenue based on assumed change in estimated selling price   1.00%                
Amount by which earned revenue would change based on assumed change in estimated selling price   $ 700                
Novartis [Member]                    
Revenue Recognition [Abstract]                    
Number of units of accounting | AccountingUnit             4      
Shares issued (in shares) | shares       1.6            
Proceeds from sale of common stock       $ 100,000            
Additional amount of common stock required to be purchased in the future                   $ 50,000
Novartis [Member] | Minimum [Member]                    
Revenue Recognition [Abstract]                    
Number of drugs with exclusive option that could be exercised | Drug             1      
Akcea [Member] | Novartis [Member]                    
Revenue Recognition [Abstract]                    
Upfront payment received       $ 75,000