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Collaborative Arrangements and Licensing Agreements, Novartis (Details)
$ in Thousands, shares in Millions
3 Months Ended
Mar. 31, 2017
USD ($)
AccountingUnit
Drug
shares
Mar. 31, 2016
USD ($)
Jan. 31, 2017
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]      
Proceeds from sale of common stock $ 71,640 $ 0  
Revenue earned $ 110,304 $ 36,874  
Novartis [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Shares issued (in shares) | shares 1.6    
Proceeds from sale of common stock $ 100,000    
Additional amount of common stock required to be purchased in the future     $ 50,000
Number of units of accounting | AccountingUnit 4    
Total consideration under collaboration $ 180,000    
Premium received on shares issued 28,400    
Potential premium received if common stock is purchased in the future at a premium 5,000    
Consideration allocated to equity 71,600    
Consideration allocated to development services and delivery of API for AKCEA-APO(a)-L and AKCEA-APOCIII-L 108,400    
Revenue earned 9,600    
Deferred revenue $ 98,800    
Novartis [Member] | Minimum [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Number of drugs with exclusive option that could be exercised | Drug 1    
Novartis [Member] | AKCEA-APO(a)-L [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Consideration allocated to development activities $ 64,000    
Consideration allocated to delivery of API 1,500    
Novartis [Member] | AKCEA-APOCIII-L [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Consideration allocated to development activities 40,100    
Consideration allocated to delivery of API 2,800    
Akcea [Member] | Novartis [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Upfront payment received 75,000    
Portion of upfront payment retained 60,000    
Portion of upfront payment paid as a sublicense fee 15,000    
License fee receivable per drug 150,000    
Next prospective milestone $ 25,000    
Percentage of license fees, milestone payments and royalties paid as sublicense fee 50.00%    
Akcea [Member] | Novartis [Member] | AKCEA-APO(a)-L [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Maximum amount of payments receivable for milestones $ 600,000    
Maximum amount of payments receivable for development milestones 25,000    
Maximum amount of payments receivable for regulatory milestones 290,000    
Maximum amount of payments receivable for commercialization milestones $ 285,000    
Royalty percentage received on sales of drug 20.00%    
Akcea [Member] | Novartis [Member] | AKCEA-APOCIII-L [Member]      
Collaborative Arrangement and Licensing Agreement [Abstract]      
Maximum amount of payments receivable for milestones $ 530,000    
Maximum amount of payments receivable for development milestones 25,000    
Maximum amount of payments receivable for regulatory milestones 240,000    
Maximum amount of payments receivable for commercialization milestones $ 265,000    
Royalty percentage received on sales of drug 20.00%