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Significant Accounting Policies, Revenue Recognition (Details)
$ in Thousands, shares in Millions
1 Months Ended 3 Months Ended 12 Months Ended
Apr. 30, 2017
USD ($)
Feb. 28, 2017
USD ($)
AccountingUnit
Mar. 31, 2017
USD ($)
AccountingUnit
Agreement
Drug
Category
Stage
shares
Mar. 31, 2016
USD ($)
Jun. 30, 2015
USD ($)
Dec. 31, 2016
Drug
Partner
Jan. 31, 2017
USD ($)
Revenue Recognition [Abstract]              
SPINRAZA royalties     $ 5,211 $ 0      
Proceeds from sale of common stock     $ 71,640 $ 0      
Number of categories of milestone events | Category     3        
Number of stages of life-cycle of drugs | Stage     3        
Number of partners that exercised option to license drugs | Partner           3  
Number of drugs licensed under option in collaboration agreements | Drug           3  
Minimum [Member]              
Revenue Recognition [Abstract]              
Period to complete IND-enabling animal studies     12 months        
Period to complete Phase 1 clinical trial     1 year        
Period to complete Phase 2 clinical trial     1 year        
Period to complete Phase 3 clinical trial     2 years        
Period to prepare and submit regulatory filings     6 months        
Period to obtain marketing authorization from applicable regulatory agency     1 year        
Pre-specified product sales threshold included in commercialization milestones     $ 1,000,000        
Maximum [Member]              
Revenue Recognition [Abstract]              
Period to complete IND-enabling animal studies     18 months        
Period to complete Phase 1 clinical trial     2 years        
Period to complete Phase 2 clinical trial     3 years        
Period to complete Phase 3 clinical trial     4 years        
Period to prepare and submit regulatory filings     12 months        
Period to obtain marketing authorization from applicable regulatory agency     2 years        
Novartis [Member]              
Revenue Recognition [Abstract]              
Number of agreements | Agreement     2        
Bayer [Member]              
Revenue Recognition [Abstract]              
Upfront payment received         $ 100,000    
Bayer [Member]              
Revenue Recognition [Abstract]              
Number of units of accounting | AccountingUnit   3          
Allocable arrangement consideration   $ 76,300          
Consideration allocated to exclusive license   64,900          
Consideration allocated to development activities   11,000          
Consideration allocated to delivery of API   $ 400          
Assumed percentage change in estimated selling price         10.00%    
Percentage change in earned revenue based on assumed change in estimated selling price         1.00%    
Amount by which earned revenue would change based on assumed change in estimated selling price         $ 700    
Bayer [Member] | Subsequent Event [Member]              
Revenue Recognition [Abstract]              
Payment received for advancing programs $ 75,000            
Novartis [Member]              
Revenue Recognition [Abstract]              
Number of units of accounting | AccountingUnit     4        
Shares issued (in shares) | shares     1.6        
Proceeds from sale of common stock     $ 100,000        
Additional amount of common stock required to be purchased in the future             $ 50,000
Novartis [Member] | Minimum [Member]              
Revenue Recognition [Abstract]              
Number of drugs with exclusive option that could be exercised | Drug     1        
Akcea [Member] | Novartis [Member]              
Revenue Recognition [Abstract]              
Upfront payment received     $ 75,000