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Collaborative Arrangements and Licensing Agreements, Research, Development and Commercialization Partners - Janssen Biotech, Inc. (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Jul. 31, 2016
USD ($)
Dec. 31, 2014
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
Program
Sep. 30, 2015
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue earned     $ 110,927 $ 49,121 $ 186,272 $ 232,133
Janssen [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue earned     10,000      
Agreement Entered Into in December 2014 [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of programs under which drugs are to be developed and commercialized | Program         3  
Upfront payment recorded as deferred revenue   $ 35,000        
Maximum amount of payments receivable for license fees and substantive milestones     800,000   $ 800,000  
Maximum amount of payments receivable for development milestones     175,000   175,000  
Maximum amount of payments receivable for regulatory milestones     420,000   420,000  
Maximum amount of payments receivable for commercialization milestones     180,000   180,000  
Cumulative payments received     47,000   47,000  
License fee received $ 10,000          
Revenue earned     12,200 $ 2,200 16,600 $ 6,600
Next prospective milestone     5,000   5,000  
Deferred revenue     $ 21,600   $ 21,600  
Agreement Entered Into in December 2014 [Member] | Revenue [Member] | Strategic Partner [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Concentration percentage     11.00% 4.00% 9.00% 3.00%