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Collaborative Arrangements and Licensing Agreements, Strategic Partnership - Biogen (Neurology) (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Feb. 29, 2016
USD ($)
Dec. 31, 2012
USD ($)
Target
Program
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Sep. 30, 2016
USD ($)
Sep. 30, 2015
USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue earned     $ 110,927 $ 49,121 $ 186,272 $ 232,133
Neurology [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Number of targets | Target   3        
Number of programs under which drugs are to be developed and commercialized | Program   3        
Upfront payment recorded as deferred revenue   $ 30,000        
Maximum amount of payment receivable per program     259,000   259,000  
Maximum amount of payments receivable per drug or program for development milestones     59,000   59,000  
Maximum amount of payments receivable per drug or program for regulatory milestones     130,000   130,000  
Cumulative payments received     43,000   43,000  
Next prospective milestone     10,000   10,000  
Neurology [Member] | IONIS-BIIB4 [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Milestone payment earned $ 3,000          
Collaboration Agreements [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Revenue earned     90,200 $ 18,100 120,900 $ 75,100
Deferred revenue     $ 73,100   $ 73,100  
Collaboration Agreements [Member] | Revenue [Member] | Strategic Partner [Member]            
Collaborative Arrangement and Licensing Agreement [Abstract]            
Concentration percentage     81.00% 37.00% 65.00% 32.00%