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Investments, Summary of Investments (Details) - USD ($)
$ in Thousands
Sep. 30, 2016
Dec. 31, 2015
Summary of Investments [Abstract]    
Cost $ 628,451 $ 667,620
Gross unrealized gains 3,290 17,660
Gross unrealized losses (1,117) (2,552)
Other-than-temporary impairment loss (525)  
Estimated fair value 630,099 682,728
Available-for-sale Securities [Member]    
Summary of Investments [Abstract]    
Cost [1] 621,289 660,458
Gross unrealized gains 545 30
Gross unrealized losses (1,117) (2,552)
Other-than-temporary impairment loss 0  
Estimated fair value 620,717 657,936
Available-for-sale Securities [Member] | Securities with Maturity of One Year or Less [Member]    
Summary of Investments [Abstract]    
Cost [1] 333,281 314,247
Gross unrealized gains 63 24
Gross unrealized losses (271) (360)
Other-than-temporary impairment loss 0  
Estimated fair value 333,073 313,911
Available-for-sale Securities [Member] | Securities with Maturity of More than One Year [Member]    
Summary of Investments [Abstract]    
Cost [1] 288,008 346,211
Gross unrealized gains 482 6
Gross unrealized losses (846) (2,192)
Other-than-temporary impairment loss 0  
Estimated fair value 287,644 344,025
Corporate Debt Securities [Member] | Securities with Maturity of One Year or Less [Member]    
Summary of Investments [Abstract]    
Cost [1] 195,953 181,670
Gross unrealized gains 36 5
Gross unrealized losses (152) (250)
Other-than-temporary impairment loss 0  
Estimated fair value 195,837 181,425
Corporate Debt Securities [Member] | Securities with Maturity of More than One Year [Member]    
Summary of Investments [Abstract]    
Cost [1] 217,980 258,703
Gross unrealized gains 457 3
Gross unrealized losses (713) (1,705)
Other-than-temporary impairment loss 0  
Estimated fair value 217,724 257,001
Debt Securities issued by U.S. Government Agencies [Member] | Securities with Maturity of One Year or Less [Member]    
Summary of Investments [Abstract]    
Cost [1] 29,512 50,559
Gross unrealized gains 11 1
Gross unrealized losses 0 (19)
Other-than-temporary impairment loss 0  
Estimated fair value 29,523 50,541
Debt Securities issued by U.S. Government Agencies [Member] | Securities with Maturity of More than One Year [Member]    
Summary of Investments [Abstract]    
Cost [1] 33,859 38,956
Gross unrealized gains 1 0
Gross unrealized losses (33) (244)
Other-than-temporary impairment loss 0  
Estimated fair value 33,827 38,712
Debt Securities issued by the U.S. Treasury [Member] | Securities with Maturity of One Year or Less [Member]    
Summary of Investments [Abstract]    
Cost [1] 28,011 [2] 2,604
Gross unrealized gains 14 0
Gross unrealized losses 0 (3)
Other-than-temporary impairment loss 0  
Estimated fair value 28,025 2,601
Debt Securities issued by States of the U.S. and Political Subdivisions of the States [Member] | Securities with Maturity of One Year or Less [Member]    
Summary of Investments [Abstract]    
Cost [1],[2] 79,805 79,414
Gross unrealized gains 2 18
Gross unrealized losses (119) (88)
Other-than-temporary impairment loss 0  
Estimated fair value 79,688 79,344
Debt Securities issued by States of the U.S. and Political Subdivisions of the States [Member] | Securities with Maturity of More than One Year [Member]    
Summary of Investments [Abstract]    
Cost [1] 36,169 48,552
Gross unrealized gains 24 3
Gross unrealized losses (100) (243)
Other-than-temporary impairment loss 0  
Estimated fair value 36,093 48,312
Equity Securities [Member]    
Summary of Investments [Abstract]    
Cost 7,162 7,162
Gross unrealized gains 2,745 17,630
Gross unrealized losses 0 0
Other-than-temporary impairment loss (525)  
Estimated fair value 9,382 24,792
Regulus Therapeutics Inc. [Member]    
Summary of Investments [Abstract]    
Cost 7,162 7,162
Gross unrealized gains 2,745 17,630
Gross unrealized losses 0 0
Other-than-temporary impairment loss (525)  
Estimated fair value $ 9,382 $ 24,792
[1] Our available-for-sale securities are held at amortized cost.
[2] Includes investments classified as cash equivalents on our condensed consolidated balance sheet.