CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 84,275	$ 128,797
Short-term investments	603,573	650,386
Contracts receivable	8,544	11,356
Inventories	9,319	6,899
Investment in Regulus Therapeutics Inc.	9,382	24,792
Other current assets	15,236	14,773
Total current assets	730,329	837,003
Property, plant and equipment, net	90,970	90,233
Patents, net	20,929	19,316
Deposits and other assets	1,358	1,348
Total assets	843,586	947,900
Current liabilities:
Accounts payable	15,680	28,355
Accrued compensation	11,008	16,065
Accrued liabilities	23,616	28,105
Current portion of long-term obligations	49	9,029
Current portion of deferred contract revenue	56,539	67,322
Total current liabilities	106,892	148,876
Long-term deferred contract revenue	101,831	134,306
Long-term obligations, less current portion	14,892	2,341
Long-term financing liability for leased facility	72,322	72,217
Total liabilities	703,947	747,110
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 121,147,433 and 120,351,480 shares issued and outstanding at September 30, 2016 and December 31, 2015, respectively	121	120
Additional paid-in capital	1,373,309	1,309,107
Accumulated other comprehensive loss	(26,498)	(13,565)
Accumulated deficit	(1,207,293)	(1,094,872)
Total stockholders' equity	139,639	200,790
Total liabilities and stockholders' equity	843,586	947,900
1 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes	356,440	339,847
2 3/4 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes	$ 51,570	$ 49,523