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Significant Accounting Policies (Tables)
 9 Months Ended
Sep. 30, 2016
Significant Accounting Policies [Abstract]  
Basic and Diluted Net Income per Share
For the three months ended September 30, 2016, we had net income. As a result, we computed diluted net income per share using the weighted-average number of common shares and dilutive common equivalent shares outstanding during those periods. Diluted common equivalent shares for the three months ended September 30, 2016, consisted of the following (in thousands except per share amounts):

Three months ended September 30, 2016
 
Income (Numerator)
  
Shares (Denominator)
  
Per-Share Amount
 
          
Income available to common shareholders
 
$
7,351
   
120,989
  
$
0.06
 
Effect of dilutive securities:
            
Shares issuable upon exercise of stock options
  
—
   
2,129
     
Shares issuable upon restricted stock award issuance
  
—
   
202
     
Shares issuable related to our ESPP
  
—
   
58
     
Income available to common shareholders, plus assumed conversions
 
$
7,351
   
123,378
  
$
0.06
 
Changes in Accumulated Other Comprehensive Income (Loss)
We include unrealized gains and losses on investments, net of taxes, in accumulated other comprehensive income (loss) along with adjustments we make to reclassify realized gains and losses on investments from other accumulated comprehensive income (loss) to our condensed consolidated statement of operations. The following table summarizes changes in accumulated other comprehensive income (loss) for the three and nine months ended September 30, 2016 and 2015 (in thousands):

 
 
Three Months Ended
September 30,
  
Nine Months Ended
September 30,
 
 
 
2016
  
2015
  
2016
  
2015
 
Beginning balance accumulated other comprehensive income (loss)
 
$
(26,853
)
 
$
18,411
  
$
(13,565
)
 
$
39,747
 
Unrealized losses on securities (1)
  
(170
)
  
(16,157
)
  
(13,458
)
  
(37,493
)
Amounts reclassified from accumulated other comprehensive income (loss)
  
525
   
(20,211
)
  
525
   
(20,211
)
Net current period other comprehensive loss
  
355
   
(36,368
)
  
(12,933
)
  
(57,704
)
Ending balance accumulated other comprehensive loss
 
$
(26,498
)
 
$
(17,957
)
 
$
(26,498
)
 
$
(17,957
)

(1)
There was no tax expense or benefit for the three and nine months ended September 30, 2016 and 2015.
Significant Accounting Policies [Abstract]  
Weighted-Average Assumptions - ESPP
ESPP:
 
Nine Months Ended
September 30,
 
2016
 
2015
Risk-free interest rate
 
0.4%
  
0.1%
Dividend yield
 
0.0%
  
0.0%
Volatility
 
86.4%
  
51.7%
Expected life
 
6 months
  
6 months
Stock-Based Compensation Expense
The following table summarizes stock-based compensation expense for the three and nine months ended September 30, 2016 and 2015 (in thousands).  Our consolidated non-cash stock-based compensation expense includes $2.9 million and $1.3 million of stock-based compensation expense for Akcea employees for the three months ended September 30, 2016 and 2015, respectively, and $9.1 million and $2.8 million of stock-based compensation expense for Akcea employees for the nine months ended September 30, 2016 and 2015, respectively.

Three Months Ended
September 30,
 
Nine Months Ended
September 30,
 
 
2016
 
2015
 
2016
 
2015
 
Research, development and patent expenses
 
$
13,279
  
$
11,297
  
$
42,541
  
$
32,248
 
General and administrative
  
4,307
   
3,700
   
14,409
   
9,659
 
Total non-cash stock-based compensation expense
 
$
17,586
  
$
14,997
  
$
56,950
  
$
41,907
 
Employee Stock Options [Member]  
Significant Accounting Policies [Abstract]  
Weighted-Average Assumptions
We use the Black-Scholes model to estimate the fair value of stock options granted and stock purchase rights under our ESPP. The expected term of stock options granted represents the period of time that we expect them to be outstanding. We estimate the expected term of options granted based on historical exercise patterns. For the nine months ended September 30, 2016 and 2015, we used the following weighted-average assumptions in our Black-Scholes calculations:

Employee Stock Options:
 
Nine Months Ended
September 30,
 
2016
 
2015
Risk-free interest rate
 
1.5%
  
1.5%
Dividend yield
 
0.0%
  
0.0%
Volatility
 
58.5%
  
53.7%
Expected life
 
4.5 years
  
4.5 years
Board of Director Stock Options [Member]  
Significant Accounting Policies [Abstract]  
Weighted-Average Assumptions
Board of Director Stock Options:
 
Nine Months Ended
September 30,
 
2016
 
2015
Risk-free interest rate
 
1.3 %
  
2.1 %
Dividend yield
 
0.0 %
  
0.0 %
Volatility
 
53.1 %
  
52.2 %
Expected life
 
6.5 years
  
6.9 years