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Segment Information and Concentration of Business Risk, Segment Information (Details)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2016
USD ($)
Jun. 30, 2015
USD ($)
Jun. 30, 2016
USD ($)
Segment
Jun. 30, 2015
USD ($)
Dec. 31, 2015
USD ($)
Segment Information and Concentration of Business Risk [Abstract]          
Number of reportable segments | Segment     2    
Revenue [Abstract]          
Research and development $ 22,455 $ 119,658 $ 57,670 $ 181,551  
Licensing and royalty 16,015 770 17,675 1,461  
Total revenue 38,470 120,428 75,345 183,012  
Income (loss) from operations (48,927) 44,646 (103,577) 35,317  
Total assets 811,109   811,109   $ 947,900
Operating Segments [Member] | Ionis Core [Member]          
Revenue [Abstract]          
Research and development 22,455 119,658 57,670 181,551  
Licensing and royalty 16,015 770 17,675 1,461  
Total revenue 38,470 120,428 75,345 183,012  
Income (loss) from operations (34,152) 53,535 (72,790) 51,210  
Total assets 883,519   883,519   995,852
Operating Segments [Member] | Akcea Therapeutics [Member]          
Revenue [Abstract]          
Research and development 0 0 0 0  
Licensing and royalty 0 0 0 0  
Total revenue 0 0 0 0  
Income (loss) from operations (14,805) (8,919) (30,847) (15,953)  
Total assets 63,728   63,728   66,306
Elimination of Intercompany Activity [Member]          
Revenue [Abstract]          
Research and development 0 0 0 0  
Licensing and royalty 0 0 0 0  
Total revenue 0 0 0 0  
Income (loss) from operations 30 $ 30 60 $ 60  
Total assets $ (136,138)   $ (136,138)   $ (114,258)