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Cumulative amount of milestone payments earned under the collaborative arrangement as of the end of the reporting period.

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No definition available.

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Cumulative amount of payments received under the collaborative arrangement as of the end of the reporting period.

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Represents the maximum amount of payments receivable under the agreement.

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No definition available.

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Represents the minimum amount of payments receivable under the agreement.

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No definition available.

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- Definition

Represents the number of drugs currently in clinical development by the collaborative partner under the agreement.

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No definition available.

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- Definition

Represents the next prospective milestone payment to be earned.

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No definition available.

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- Definition

Represents the amount of upfront fees received during the period under the agreement.

+ References

No definition available.

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- Definition

Amount of deferred revenue as of balance sheet date. Deferred revenue represents collections of cash or other assets related to a revenue producing activity for which revenue has not yet been recognized. Generally, an entity records deferred revenue when it receives consideration from a customer before achieving certain criteria that must be met for revenue to be recognized in conformity with GAAP.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 605

-SubTopic 10

-Section S99

-Paragraph 1

-Subparagraph (SAB TOPIC 13.A.4(a).Q1 Response)

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Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Staff Accounting Bulletin (SAB)

-Number Topic 13

-Section A

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The amount of consideration recognized during the period for the milestone or milestones.

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Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 605

-SubTopic 28

-Section 50

-Paragraph 2

-Subparagraph (e)

-URI http://asc.fasb.org/extlink&oid=51671726&loc=SL6892177-166501

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- Definition

Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 225

-SubTopic 10

-Section S99

-Paragraph 2

-Subparagraph (SX 210.5-03.1)

-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

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Collaborative Arrangements and Licensing Agreements, Traditional Pharmaceutical Alliances and Licensing - GlaxoSmithKline (Details) $ in Thousands	1 Months Ended		3 Months Ended		9 Months Ended
	Oct. 31, 2015 USD ($)	Mar. 31, 2010 USD ($)	Sep. 30, 2015 USD ($)	Sep. 30, 2014 USD ($)	Sep. 30, 2015 USD ($) Drug	Sep. 30, 2014 USD ($)
Collaborative Arrangement and Licensing Agreement [Abstract]
Revenue earned			$ 49,121	$ 44,063	$ 232,133	$ 129,300
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of drugs currently in development \| Drug					5
Upfront fee received		$ 38,000
Next prospective milestone			1,500		$ 1,500
Cumulative payments received			129,500		129,500
Revenue earned			1,600	$ 5,100	22,400	$ 11,900
Deferred revenue			5,500		5,500
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| Pre-specified Events [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Minimum amount of payments receivable			1,300,000		1,300,000
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| Development Milestones [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable			223,500		223,500
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| Regulatory Milestones [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable			483,500		483,500
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| Commercialization Milestones [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Maximum amount of payments receivable			428,000		428,000
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| ISIS-TTR [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Cumulative milestone payments earned			60,000		60,000
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| ISIS-TTR [Member] \| Development Milestones [Member] \| Phase 2/3 Study [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Next prospective milestone			$ 10,000		$ 10,000
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| ISIS-GSK4 [Member] \| Subsequent Event [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Milestone payment earned	$ 5,000
Glaxo Smith Kline [Member] \| Collaborations and Licensing Agreements [Member] \| ISIS-HBV, ISIS-GSK4-L, ISIS-RHO-2.5, and ISIS-GSK6-L [Member]
Collaborative Arrangement and Licensing Agreement [Abstract]
Number of drugs currently in development \| Drug					4