CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($) $ in Thousands	Sep. 30, 2015	Dec. 31, 2014
Current assets:
Cash and cash equivalents	$ 126,593	$ 142,998
Short-term investments	685,599	585,834
Contracts receivable	1,826	3,903
Inventories	6,583	6,290
Investment in Regulus Therapeutics Inc.	18,594	81,881
Other current assets	29,066	15,691
Total current assets	868,261	836,597
Property, plant and equipment, net	89,243	88,958
Licenses, net	1,285	2,690
Patents, net	19,489	17,186
Deposits and other assets	9,727	10,378
Total assets	988,005	955,809
Current liabilities:
Accounts payable	19,294	17,984
Accrued compensation	9,508	12,302
Accrued liabilities	24,487	30,451
Current portion of long-term obligations	773	2,882
Current portion of deferred contract revenue	68,136	51,713
Total current liabilities	122,198	115,332
Long-term deferred contract revenue	149,100	127,797
Long-term obligations, less current portion	7,312	7,669
Long-term financing liability for leased facility	72,091	71,731
Total liabilities	742,591	698,029
Stockholders' equity:
Common stock, $0.001 par value; 300,000,000 shares authorized, 120,028,312 and 118,442,726 shares issued and outstanding at September 30, 2015 and December 31, 2014, respectively	120	118
Additional paid-in capital	1,286,690	1,224,509
Accumulated other comprehensive (loss) income	(17,957)	39,747
Accumulated deficit	(1,023,439)	(1,006,594)
Total stockholders' equity	245,414	257,780
Total liabilities and stockholders' equity	988,005	955,809
1 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes	342,136	327,486
2 3/4 Percent Convertible Senior Notes [Member]
Current liabilities:
Convertible senior notes	$ 49,754	$ 48,014