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Significant Accounting Policies (Tables)
 9 Months Ended
Sep. 30, 2015
Significant Accounting Policies [Abstract]  
Changes in Accumulated Other Comprehensive Income
Accumulated other comprehensive (loss) income is comprised of unrealized gains and losses on investments, net of taxes, and adjustments we made to reclassify realized gains and losses on investments from other accumulated comprehensive (loss) income to our condensed consolidated statement of operations. The following table summarizes changes in accumulated other comprehensive (loss) income for the three and nine months ended September 30, 2015 and 2014 (in thousands):

 
 
Three Months Ended September 30,
  
Nine Months Ended September 30,
 
 
 
2015
  
2014
  
2015
  
2014
 
Beginning balance accumulated other comprehensive income
 
$
18,411
  
$
24,719
  
$
39,747
  
$
21,080
 
Unrealized losses on securities, net of tax (1)
  
(16,157
)
  
(6,994
)
  
(37,493
)
  
(3,189
)
Amounts reclassified from accumulated other comprehensive (loss) income (2)
  
(20,211
)
  
(831
)
  
(20,211
)
  
(997
)
Net other comprehensive loss for the period
  
(36,368
)
  
(7,825
)
  
(57,704
)
  
(4,186
)
Ending balance accumulated other comprehensive (loss) income
 
$
(17,957
)
 
$
16,894
  
$
(17,957
)
 
$
16,894
 

(1)Other comprehensive loss for the three months ended September 30, 2014 included income tax benefit of $2.5 million. There was no tax expense or benefit for the three and nine months ended September 30, 2015 and the nine months ended September 30, 2014.

(2)Amounts for the three and nine months ended September 30, 2015 are included in gain on investment in Regulus Therapeutics Inc. on our condensed consolidated statement of operations. For the three and nine months ended September 30, 2014, $0.5 million is included in the gain on investment in Regulus Therapeutics Inc., with the remaining amount included in gain on investments, net on our condensed consolidated statement of operations.
Significant Accounting Policies [Abstract]  
Weighted-Average Assumptions - ESPP
ESPP:
 
Nine Months Ended
September 30,
 
2015
 
2014
Risk-free interest rate
 
0.1%
  
0.1%
Dividend yield
 
0.0%
  
0.0%
Volatility
 
51.7%
  
60.6%
Expected life
 
6 months
  
6 months
Stock-Based Compensation Expense
The following table summarizes stock-based compensation expense for the three and nine months ended September 30, 2015 and 2014 (in thousands), which was allocated as follows:

 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
 
2015
 
2014
 
2015
 
2014
 
Research, development and patent expenses
 
$
11,297
  
$
6,606
  
$
32,248
  
$
18,879
 
General and administrative
  
3,700
   
1,512
   
9,659
   
4,015
 
Total
 
$
14,997
  
$
8,118
  
$
41,907
  
$
22,894
 
Employee Stock Options [Member]  
Significant Accounting Policies [Abstract]  
Weighted-Average Assumptions
We use the Black-Scholes model to estimate the fair value of stock options granted and stock purchase rights under our ESPP. The expected term of stock options granted represents the period of time that we expect them to be outstanding. We estimate the expected term of options granted based on historical exercise patterns. For the nine months ended September 30, 2015 and 2014, we used the following weighted-average assumptions in our Black-Scholes calculations:

Employee Stock Options:
 
Nine Months Ended
September 30,
 
2015
 
2014
Risk-free interest rate
 
1.5%
  
1.6%
Dividend yield
 
0.0%
  
0.0%
Volatility
 
53.7%
  
50.7%
Expected life
 
4.5 years
  
4.6 years
Board of Director Stock Options [Member]  
Significant Accounting Policies [Abstract]  
Weighted-Average Assumptions
Board of Director Stock Options:

 
Nine Months Ended
September 30,
 
2015
 
2014
Risk-free interest rate
 
2.1 %
  
2.2 %
Dividend yield
 
0.0 %
  
0.0 %
Volatility
 
52.2 %
  
54.2 %
Expected life
 
6.9 years
  
6.9 years