0000874015-15-000080.txt : 20151104 0000874015-15-000080.hdr.sgml : 20151104 20151104190000 ACCESSION NUMBER: 0000874015-15-000080 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20151103 FILED AS OF DATE: 20151104 DATE AS OF CHANGE: 20151104 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: O'NEIL PATRICK R. CENTRAL INDEX KEY: 0001564926 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 151198391 MAIL ADDRESS: STREET 1: C/O ISIS PHARMACEUTICALS, INC. STREET 2: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0306 4 2015-11-03 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001564926 O'NEIL PATRICK R. C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 SVP, Legal & General Counsel Common Stock 2015-11-03 2015-11-03 4 M 0 1000 7.25 A 7259 D Common Stock 2015-11-03 2015-11-03 4 S 0 1000 51.95 D 6259 D Employee Stock Option (right to buy) 7.25 2015-11-03 2015-11-03 4 M 0 1000 0 D 2013-01-03 2019-01-02 Common Stock 1000 3067 D Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 9/21/2015. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.50 to $52.40, inclusive. The reporting person undertakes to provide to Isis Pharmaceuticals, Inc., any security holder of Isis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4. Grant of 1/3/2012 to reporting person of stock options under the Isis Pharmacueticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vested and became exercisable on 1/3/2013. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments, at the rate of 4,875 shares per year. Following this transaction, the option was exercisable as to 2,254 on 11/3/2015. /s/Patrick O'Neil 2015-11-04