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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) (Parenthetical)
Mar. 31, 2015
Dec. 31, 2014
Mar. 31, 2014
1 Percent Convertible Senior Notes [Member]      
Adjustments to reconcile net loss to net cash (used in) operating activities:      
Interest rate on convertible notes (in hundredths) 1.00%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes1PercentMember
1.00%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes1PercentMember
 
2 3/4 Percent Convertible Senior Notes [Member]      
Adjustments to reconcile net loss to net cash (used in) operating activities:      
Interest rate on convertible notes (in hundredths) 2.75%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes275PercentMember
2.75%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes275PercentMember
2.75%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes275PercentMember