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Segment Information and Concentration of Business Risk (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 12 Months Ended
Mar. 31, 2015
Segment
Mar. 31, 2014
Dec. 31, 2014
Partner
Segment Information and Concentration of Business Risk [Abstract]      
Number of reportable segments 2us-gaap_NumberOfReportableSegments    
Revenues [Abstract]      
Research and development revenue $ 61,892isis_ResearchAndDevelopmentRevenueUnderCollaborativeAgreements $ 19,550isis_ResearchAndDevelopmentRevenueUnderCollaborativeAgreements  
Licensing and royalty 691isis_LicensingAndRoyaltyRevenue 8,611isis_LicensingAndRoyaltyRevenue  
Total revenue 62,583us-gaap_Revenues 28,161us-gaap_Revenues  
Loss from operations (9,330)us-gaap_OperatingIncomeLoss (29,667)us-gaap_OperatingIncomeLoss  
Revenue [Member] | Partner A [Member]      
Concentration Risk [Line Items]      
Concentration percentage (in hundredths) 63.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_RevenueFromPartnerMember
36.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_RevenueFromPartnerMember
 
Revenue [Member] | Partner B [Member]      
Concentration Risk [Line Items]      
Concentration percentage (in hundredths) 26.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_RevenueFromPartnerBMember
12.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_RevenueFromPartnerBMember
 
Revenue [Member] | Partner C [Member]      
Concentration Risk [Line Items]      
Concentration percentage (in hundredths) 1.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_PartnerCMember
12.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_PartnerCMember
 
Revenue [Member] | Partner D [Member]      
Concentration Risk [Line Items]      
Concentration percentage (in hundredths) 0.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_PartnerDMember
27.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_SalesRevenueGoodsNetMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_PartnerDMember
 
Contract Receivables [Member] | Significant Partners [Member]      
Concentration Risk [Line Items]      
Concentration percentage (in hundredths) 92.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_AccountsReceivableSignificantPartnersMember
  99.00%us-gaap_ConcentrationRiskPercentage1
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_AccountsReceivableSignificantPartnersMember
Number of significant partners 2isis_NumberOfSignificantPartners
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_AccountsReceivableSignificantPartnersMember
  3isis_NumberOfSignificantPartners
/ us-gaap_ConcentrationRiskByBenchmarkAxis
= us-gaap_AccountsReceivableMember
/ us-gaap_ConcentrationRiskByTypeAxis
= isis_AccountsReceivableSignificantPartnersMember
Operating Segments [Member] | Isis Core [Member]      
Revenues [Abstract]      
Research and development revenue 61,892isis_ResearchAndDevelopmentRevenueUnderCollaborativeAgreements
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_IsisCoreMember
   
Licensing and royalty 691isis_LicensingAndRoyaltyRevenue
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_IsisCoreMember
   
Total revenue 62,583us-gaap_Revenues
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_IsisCoreMember
   
Loss from operations (2,232)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_IsisCoreMember
   
Operating Segments [Member] | Akcea [Member]      
Revenues [Abstract]      
Research and development revenue 0isis_ResearchAndDevelopmentRevenueUnderCollaborativeAgreements
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_AkceaMember
   
Licensing and royalty 0isis_LicensingAndRoyaltyRevenue
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_AkceaMember
   
Total revenue 0us-gaap_Revenues
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_AkceaMember
   
Loss from operations $ (7,098)us-gaap_OperatingIncomeLoss
/ us-gaap_ConsolidationItemsAxis
= us-gaap_OperatingSegmentsMember
/ us-gaap_StatementBusinessSegmentsAxis
= isis_AkceaMember