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CONDENSED CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) (USD $)
Mar. 31, 2015
Dec. 31, 2014
Stockholders' equity:    
Common stock, par value (in dollars per share) 0.001us-gaap_CommonStockParOrStatedValuePerShare 0.001us-gaap_CommonStockParOrStatedValuePerShare
Common stock, shares authorized (in shares) 300,000,000us-gaap_CommonStockSharesAuthorized 300,000,000us-gaap_CommonStockSharesAuthorized
Common stock, shares issued (in shares) 119,602,322us-gaap_CommonStockSharesIssued 118,442,726us-gaap_CommonStockSharesIssued
Common stock, shares outstanding (in shares) 119,602,322us-gaap_CommonStockSharesOutstanding 118,442,726us-gaap_CommonStockSharesOutstanding
1 Percent Convertible Senior Notes [Member]    
LIABILITIES AND STOCKHOLDERS' EQUITY    
Interest rate on convertible senior notes (in hundredths) 1.00%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes1PercentMember
1.00%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes1PercentMember
2 3/4 Percent Convertible Senior Notes [Member]    
LIABILITIES AND STOCKHOLDERS' EQUITY    
Interest rate on convertible senior notes (in hundredths) 2.75%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes275PercentMember
2.75%us-gaap_DebtInstrumentInterestRateStatedPercentage
/ us-gaap_DebtInstrumentAxis
= isis_ConvertibleSeniorNotes275PercentMember