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Significant Accounting Policies, Cash, Cash Equivalents and Short-term Investments, Inventory Valuation, and Research, Development and Patent Expenses (Details) (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Dec. 31, 2014
Inventory valuation [Abstract]    
Raw materials 6,839us-gaap_InventoryRawMaterialsNetOfReserves $ 6,290us-gaap_InventoryRawMaterialsNetOfReserves
Maximum [Member] | Privately- and Publicly-Held Biotechnology Companies [Member]    
Schedule of Equity Method Investments [Line Items]    
Ownership percentage in equity investments (in hundredths) 20.00%isis_EquityInvestmentsOtherThanEquityMethodOwnershipPercentage
/ us-gaap_RangeAxis
= us-gaap_MaximumMember
/ us-gaap_ScheduleOfEquityMethodInvestmentEquityMethodInvesteeNameAxis
= isis_PrivatelyAndPubliclyHeldBiotechnologyCompaniesMember