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Segment Information and Concentration of Business Risk (Tables)
3 Months Ended
Mar. 31, 2015
Segment Information and Concentration of Business Risk [Abstract]  
Segment Information
The following is our segment information for the three months ended March 31, 2015 (in thousands).

 
Isis Core
 
Akcea Therapeutics
 
Total
 
    
Revenue:
   
Research and development
 
$
61,892
  
$
  
$
61,892
 
Licensing and royalty
  
691
   
   
691
 
Total segment revenue
 
$
62,583
  
$
  
$
62,583
 
Loss from operations
 
$
(2,232
)
 
$
(7,098
)
 
$
(9,330
)

Schedule of revenue from significant partners
We have historically funded our operations from collaborations with corporate partners and a relatively small number of partners have accounted for a significant percentage of our revenue. Revenue from significant partners, which is defined as ten percent or more of our total revenue, was as follows:

 
Three Months Ended
March 31,
 
2015
 
2014
Partner A
 
63%
  
36%
Partner B
 
26%
  
12%
Partner C
 
1%
  
12%
Partner D
 
0%
  
27%