<SEC-DOCUMENT>0000874015-15-000002-index.html : 20150105
<SEC-HEADER>0000874015-15-000002.hdr.sgml : 20150105
<ACCEPTANCE-DATETIME>20150105195610
ACCESSION NUMBER:		0000874015-15-000002
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20150101
FILED AS OF DATE:		20150105
DATE AS OF CHANGE:		20150105

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ISIS PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000874015
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				330336973
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
		BUSINESS PHONE:		7609319200

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Monia Brett P
		CENTRAL INDEX KEY:			0001537529

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-19125
		FILM NUMBER:		15507685

	MAIL ADDRESS:	
		STREET 1:		2855 GAZELLE COURT
		STREET 2:		C/O ISIS PHARMACEUTICALS, INC.
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92010
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>edgar.xml
<DESCRIPTION>PRIMARY DOCUMENT
<TEXT>
Document 1 - file: edgar.html

Document 1 - RAW XML: edgar.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>moniapoa.htm
<TEXT>
Document 2 - file: moniapoa.htm

</DOCUMENT>
</SEC-DOCUMENT>