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Investments, Summary of Investments and Investments Temporarily Impaired (Details) (USD $)
In Thousands, unless otherwise specified
Sep. 30, 2014
Investment
Dec. 31, 2013
Investments    
Cost Basis $ 550,614 $ 527,873
Unrealized Gains 33,435 37,535
Unrealized Losses (704) (619)
Other-Than-Temporary Impairment Loss (1,269) (880)
Estimated Fair Value 582,076 563,909
Temporarily impaired investments [Abstract]    
Temporarily impaired securities, Number of Investments 207  
Temporarily impaired securities, Less than 12 months of temporary impairment, Estimated Fair Value 244,340  
Temporarily impaired securities, Less than 12 months of temporary impairment, Unrealized Losses (642)  
Temporarily impaired securities, More than 12 months of temporary impairment, Estimated Fair Value 9,494  
Temporarily impaired securities, More than 12 months of temporary impairment, Unrealized Losses (62)  
Total temporary impairment, Estimated Fair Value 253,834  
Total temporary impairment, Unrealized Losses (704)  
Available-for-sale securities [Member]
    
Investments    
Amortized Cost 534,029 510,184
Unrealized Gains 304 347
Unrealized Losses (704) (619)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 533,629 509,912
Available-for-sale securities [Member] | Debt maturities of one year or less [Member]
    
Investments    
Amortized Cost 304,150 179,659
Unrealized Gains 203 109
Unrealized Losses (150) (71)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 304,203 179,697
Available-for-sale securities [Member] | Debt maturities of more than one year [Member]
    
Investments    
Amortized Cost 229,879 330,525
Unrealized Gains 101 238
Unrealized Losses (554) (548)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 229,426 330,215
Corporate debt securities [Member]
    
Temporarily impaired investments [Abstract]    
Temporarily impaired securities, Number of Investments 178  
Temporarily impaired securities, Less than 12 months of temporary impairment, Estimated Fair Value 165,321  
Temporarily impaired securities, Less than 12 months of temporary impairment, Unrealized Losses (397)  
Temporarily impaired securities, More than 12 months of temporary impairment, Estimated Fair Value 9,266  
Temporarily impaired securities, More than 12 months of temporary impairment, Unrealized Losses (15)  
Total temporary impairment, Estimated Fair Value 174,587  
Total temporary impairment, Unrealized Losses (412)  
Corporate debt securities [Member] | Debt maturities of one year or less [Member]
    
Investments    
Amortized Cost 205,973 [1] 142,096 [2]
Unrealized Gains 153 [1] 75 [2]
Unrealized Losses (67) [1] (27) [2]
Other-Than-Temporary Impairment Loss 0 [1] 0 [2]
Estimated Fair Value 206,059 [1] 142,144 [2]
Corporate debt securities [Member] | Debt maturities of more than one year [Member]
    
Investments    
Amortized Cost 148,079 265,969
Unrealized Gains 55 177
Unrealized Losses (345) (393)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 147,789 265,753
Debt securities issued by U.S. government agencies [Member]
    
Temporarily impaired investments [Abstract]    
Temporarily impaired securities, Number of Investments 10  
Temporarily impaired securities, Less than 12 months of temporary impairment, Estimated Fair Value 56,358  
Temporarily impaired securities, Less than 12 months of temporary impairment, Unrealized Losses (167)  
Temporarily impaired securities, More than 12 months of temporary impairment, Estimated Fair Value 0  
Temporarily impaired securities, More than 12 months of temporary impairment, Unrealized Losses 0  
Total temporary impairment, Estimated Fair Value 56,358  
Total temporary impairment, Unrealized Losses (167)  
Debt securities issued by U.S. government agencies [Member] | Debt maturities of one year or less [Member]
    
Investments    
Amortized Cost 51,021 [1] 23,242 [2]
Unrealized Gains 13 [1] 22 [2]
Unrealized Losses (35) [1] (16) [2]
Other-Than-Temporary Impairment Loss 0 [1] 0 [2]
Estimated Fair Value 50,999 [1] 23,248 [2]
Debt securities issued by U.S. government agencies [Member] | Debt maturities of more than one year [Member]
    
Investments    
Amortized Cost 55,525 41,308
Unrealized Gains 5 3
Unrealized Losses (132) (127)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 55,398 41,184
Debt securities issued by the U.S. Treasury [Member] | Debt maturities of one year or less [Member]
    
Investments    
Amortized Cost 9,022 6,239
Unrealized Gains 18 6
Unrealized Losses 0 0
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 9,040 6,245
Debt securities issued by the U.S. Treasury [Member] | Debt maturities of more than one year [Member]
    
Investments    
Amortized Cost   9,062
Unrealized Gains   21
Unrealized Losses   0
Other-Than-Temporary Impairment Loss   0
Estimated Fair Value   9,083
Debt securities issued by states of the United States and political subdivisions of the states [Member]
    
Temporarily impaired investments [Abstract]    
Temporarily impaired securities, Number of Investments 19  
Temporarily impaired securities, Less than 12 months of temporary impairment, Estimated Fair Value 22,661  
Temporarily impaired securities, Less than 12 months of temporary impairment, Unrealized Losses (78)  
Temporarily impaired securities, More than 12 months of temporary impairment, Estimated Fair Value 228  
Temporarily impaired securities, More than 12 months of temporary impairment, Unrealized Losses (47)  
Total temporary impairment, Estimated Fair Value 22,889  
Total temporary impairment, Unrealized Losses (125)  
Debt securities issued by states of the United States and political subdivisions of the states [Member] | Debt maturities of one year or less [Member]
    
Investments    
Amortized Cost 38,134 8,082
Unrealized Gains 19 6
Unrealized Losses (48) (28)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 38,105 8,060
Debt securities issued by states of the United States and political subdivisions of the states [Member] | Debt maturities of more than one year [Member]
    
Investments    
Amortized Cost 26,275 14,186
Unrealized Gains 41 37
Unrealized Losses (77) (28)
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value 26,239 14,195
Equity securities [Member]
    
Investments    
Cost Basis 16,585 17,689
Unrealized Gains 33,131 37,188
Unrealized Losses 0 0
Other-Than-Temporary Impairment Loss (1,269) (880)
Estimated Fair Value 48,447 53,997
Equity securities [Member] | Securities included in other current assets [Member]
    
Investments    
Cost Basis 1,269 1,538
Unrealized Gains 1,021 618
Unrealized Losses 0 0
Other-Than-Temporary Impairment Loss (1,269) (880)
Estimated Fair Value 1,021 1,276
Equity securities [Member] | Securities included in deposits and other assets [Member]
    
Investments    
Cost Basis   625
Unrealized Gains   0
Unrealized Losses   0
Other-Than-Temporary Impairment Loss   0
Estimated Fair Value   625
Equity securities [Member] | Regulus Therapeutics Inc. [Member]
    
Investments    
Cost Basis 15,316 15,526
Unrealized Gains 32,110 36,570
Unrealized Losses 0 0
Other-Than-Temporary Impairment Loss 0 0
Estimated Fair Value $ 47,426 $ 52,096
[1] Includes investments classified as cash equivalents on our condensed consolidated balance sheet.
[2] Includes investments classified as cash equivalents on our consolidated balance sheet.