Significant Accounting Policies (Tables)

9 Months Ended

Sep. 30, 2014

Significant Accounting Policies [Abstract]

Changes in accumulated other comprehensive income related to unrealized gains and losses on securities

Accumulated other comprehensive income is comprised of unrealized gains and losses on securities, net of taxes, and  adjustments we made to reclassify realized gains and losses on securities from other accumulated comprehensive income to our condensed consolidated statement of operations. The following table summarizes changes in accumulated other comprehensive income for the three and nine months ended September 30, 2014 and 2013 (in thousands):

	Three Months Ended September 30,						Nine Months Ended September 30,
	2014			2013			2014			2013
Beginning balance accumulated other comprehensive income	$	24,719		$	26,986		$	21,080		$	12,480
Unrealized (losses) gains on securities, net of tax (1)		(6,994	)		2,207			(3,189	)		17,876
Amounts reclassified from accumulated other comprehensive income (2)		(831	)		(172	)		(997	)		(1,335	)
Net current period other comprehensive (loss) income		(7,825	)		2,035			(4,186	)		16,541
Ending balance accumulated other comprehensive income	$	16,894		$	29,021		$	16,894		$	29,021

(1) Other comprehensive (loss) income for the three months ended September 30, 2014 included income tax benefit of $2.5 million, compared to income tax expense of $1.4 million and $11.4 million for the three and nine months ended September 30, 2013, respectively. We recorded no income tax benefit or expense for the nine months ended September 30, 2014.

(2) Included in gain on investments, net on our condensed consolidated statement of operations.

Stock-based compensation expense

Schedule of weighted-average assumptions used for valuation of ESPP

ESPP:

	Nine Months Ended September 30,
	2014		2013
Risk-free interest rate		0.1%		0.1%
Dividend yield		0.0%		0.0%
Volatility		60.6%		62.9%
Expected life		6 months		6 months

Schedule of stock-based compensation expense

The following table summarizes stock-based compensation expense for the three and nine months ended September 30, 2014 and 2013 (in thousands), which was allocated as follows:

	Three Months Ended September 30,						Nine Months Ended September 30,
	2014			2013			2014			2013
Research, development and patent expenses		$	6,606		$	2,373		$	18,879		$	7,171
General and administrative			1,512			439			4,015			1,147
Total		$	8,118		$	2,812		$	22,894		$	8,318

Employee Stock Options [Member]

Stock-based compensation expense

Schedule of weighted-average assumptions used for valuation of stock options

We use the Black-Scholes model to estimate the fair value of stock options granted and stock purchase rights under our ESPP. The expected term of stock options granted represents the period of time that we expect them to be outstanding.  We estimate the expected term of options granted based on historical exercise patterns. For the nine months ended September 30, 2014 and 2013, we used the following weighted-average assumptions in our Black-Scholes calculations:

Employee Stock Options:

	Nine Months Ended September 30,
	2014		2013
Risk-free interest rate		1.6%		1.0%
Dividend yield		0.0%		0.0%
Volatility		50.7%		51.4%
Expected life		4.6 years		5.1 years

Board of Director Stock Option [Member]

Stock-based compensation expense

Schedule of weighted-average assumptions used for valuation of stock options

Board of Director Stock Options:

	Nine Months Ended September 30,
	2014		2013
Risk-free interest rate		2.2%		2.2%
Dividend yield		0.0%		0.0%
Volatility		54.2%		52.7%
Expected life		6.9 years		7.2 years