0000874015-14-000080.txt : 20140828 0000874015-14-000080.hdr.sgml : 20140828 20140828184843 ACCESSION NUMBER: 0000874015-14-000080 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20140826 FILED AS OF DATE: 20140828 DATE AS OF CHANGE: 20140828 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: ISIS PHARMACEUTICALS INC CENTRAL INDEX KEY: 0000874015 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 330336973 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 BUSINESS PHONE: 7609319200 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT CITY: CARLSBAD STATE: CA ZIP: 92010 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Monia Brett P CENTRAL INDEX KEY: 0001537529 FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 000-19125 FILM NUMBER: 141072983 MAIL ADDRESS: STREET 1: 2855 GAZELLE COURT STREET 2: C/O ISIS PHARMACEUTICALS, INC. CITY: CARLSBAD STATE: CA ZIP: 92010 4 1 edgar.xml PRIMARY DOCUMENT X0306 4 2014-08-26 0000874015 ISIS PHARMACEUTICALS INC ISIS 0001537529 Monia Brett P C/O ISIS PHARMACEUTICALS, INC. 2855 GAZELLE COURT CARLSBAD CA 92010 0 1 0 0 SVP, Antisense Drug Discovery Common Stock 2014-08-26 2014-08-26 4 M 0 2344 11.27 A 4157 D Common Stock 2014-08-26 2014-08-26 4 S 0 2344 38.144 D 1813 D Common Stock 2014-08-26 2014-08-26 4 M 0 15000 10.29 A 16813 D Common Stock 2014-08-26 2014-08-26 4 S 0 15000 38.144 D 1813 D Common Stock 2014-08-26 2014-08-26 4 M 0 10000 7.25 A 11813 D Common Stock 2014-08-26 2014-08-26 4 S 0 10000 38.144 D 1813 D Employee Stock Option (right to buy) 11.27 2014-08-26 2014-08-26 4 M 0 2344 0 D 2014-01-04 2017-01-03 Common Stock 2344 0 D Employee Stock Option (right to buy) 10.29 2014-08-26 2014-08-26 4 M 0 15000 0 D 2012-01-03 2018-01-02 Common Stock 15000 5245 D Employee Stock Option (right to buy) 7.25 2014-08-26 2014-08-26 4 M 0 10000 0 D 2013-01-03 2019-01-02 Common Stock 10000 2266 D Acquired as a result of exercising a stock option pursuant to a Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 7/1/14. Grant of 1/3/11 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vest and became exercisable on 1/3/12. Thereafter, the remaining shares subject to the option vest and became exercisable in 36 equal monthly installments, at the rate of 5,650 shares per year. The option shall be fully vested and exercisable on 1/3/15. The option, before the reported exercises, was exercisable as to 20,245 shares on 8/26/14. Grant of 1/3/12 to reporting person of stock options under the Isis Pharmaceuticals, Inc. 1989 Stock Option Plan. 25% of the shares subject to the option vest and became exercisable on 1/3/13. Thereafter, the remaining shares subject to the option vest and became exercisable in 36 equal monthly installments, at the rate of 4,749 shares per year. The option shall be fully vested and exercisable on 1/3/16. The option, before the reported exercises, was exercisable as to 12,266 shares on 8/26/14. /s/Brett P. Monia 2014-08-28